Linked Life Data

11910117

Source:http://linkedlifedata.com/resource/pubmed/id/11910117

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5563
pubmed:dateCreated
2002-3-22
pubmed:abstractText
Activity-dependent modulation of synaptic efficacy in the brain contributes to neural circuit development and experience-dependent plasticity. Although glia are affected by activity and ensheathe synapses, their influence on synaptic strength has largely been ignored. Here, we show that a protein produced by glia, tumor necrosis factor alpha (TNFalpha), enhances synaptic efficacy by increasing surface expression of AMPA receptors. Preventing the actions of endogenous TNFalpha has the opposite effects. Thus, the continual presence of TNFalpha is required for preservation of synaptic strength at excitatory synapses. Through its effects on AMPA receptor trafficking, TNFalpha may play roles in synaptic plasticity and modulating responses to neural injury.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1095-9203
pubmed:author
pubmed:issnType
Electronic
pubmed:day
22
pubmed:volume
295
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2282-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11910117-Animals, pubmed-meshheading:11910117-Antigens, CD, pubmed-meshheading:11910117-Astrocytes, pubmed-meshheading:11910117-Cells, Cultured, pubmed-meshheading:11910117-Culture Media, Conditioned, pubmed-meshheading:11910117-Gene Expression Regulation, pubmed-meshheading:11910117-Hippocampus, pubmed-meshheading:11910117-Neuronal Plasticity, pubmed-meshheading:11910117-Neurons, pubmed-meshheading:11910117-Rats, pubmed-meshheading:11910117-Rats, Sprague-Dawley, pubmed-meshheading:11910117-Receptors, AMPA, pubmed-meshheading:11910117-Receptors, Tumor Necrosis Factor, pubmed-meshheading:11910117-Receptors, Tumor Necrosis Factor, Type I, pubmed-meshheading:11910117-Synapses, pubmed-meshheading:11910117-Synaptic Transmission, pubmed-meshheading:11910117-Tumor Necrosis Factor-alpha
pubmed:year
2002
pubmed:articleTitle
Control of synaptic strength by glial TNFalpha.
pubmed:affiliation
Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA. beattie.2@osu.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.