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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-3-22
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pubmed:abstractText |
Proton pump inhibitors (PPI) and misoprostol decrease the risk of development of nonsteroidal antiinflammatory drug induced gastric ulcers and aid healing of upper gastrointestinal (GI) ulcers. H2 receptor antagonists (H2RA) are less effective for this task, but are widely used by patients and physicians for the treatment of GI symptoms and duodenal ulcers. Sucralfate is a weaker agent that is sometimes used for prophylaxis or treatment of upper GI ulcers. We investigated the effect of GI drugs and selective and nonselective NSAID on the incidence of GI ulcer development in a cohort of patients immediately after the release of celecoxib and rofecoxib to investigate the effect of confounding by indication when effective GI agents and cyclooxygenase 2 (COX-2)-specific inhibitors are prescribed to a high risk population.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Gastrointestinal Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine H2 Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Proton Pumps
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0315-162X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
467-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11908558-Aged,
pubmed-meshheading:11908558-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:11908558-Cyclooxygenase 2,
pubmed-meshheading:11908558-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:11908558-Cyclooxygenase Inhibitors,
pubmed-meshheading:11908558-Drug Interactions,
pubmed-meshheading:11908558-Female,
pubmed-meshheading:11908558-Gastrointestinal Agents,
pubmed-meshheading:11908558-Histamine H2 Antagonists,
pubmed-meshheading:11908558-Humans,
pubmed-meshheading:11908558-Incidence,
pubmed-meshheading:11908558-Isoenzymes,
pubmed-meshheading:11908558-Male,
pubmed-meshheading:11908558-Membrane Proteins,
pubmed-meshheading:11908558-Middle Aged,
pubmed-meshheading:11908558-Peptic Ulcer,
pubmed-meshheading:11908558-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:11908558-Proton Pumps,
pubmed-meshheading:11908558-Questionnaires,
pubmed-meshheading:11908558-Rheumatic Diseases,
pubmed-meshheading:11908558-Risk Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Gastroprotective therapy and risk of gastrointestinal ulcers: risk reduction by COX-2 therapy.
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pubmed:affiliation |
National Data Bank for Rheumatic Diseases-Arthritis Research Center Foundation and University of Kansas School of Medicine, Wichita 67214, USA. fwolfe@arthritis-research.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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