| pubmed-article:11907116 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11907116 | lifeskim:mentions | umls-concept:C0812246 | lld:lifeskim |
| pubmed-article:11907116 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:11907116 | lifeskim:mentions | umls-concept:C0108747 | lld:lifeskim |
| pubmed-article:11907116 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:11907116 | lifeskim:mentions | umls-concept:C1367477 | lld:lifeskim |
| pubmed-article:11907116 | lifeskim:mentions | umls-concept:C1414555 | lld:lifeskim |
| pubmed-article:11907116 | lifeskim:mentions | umls-concept:C0449416 | lld:lifeskim |
| pubmed-article:11907116 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:11907116 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:11907116 | pubmed:dateCreated | 2002-3-21 | lld:pubmed |
| pubmed-article:11907116 | pubmed:abstractText | In human blood two monocyte populations can be distinguished, i.e., the CD14(++)CD16(-)DR(+) classical monocytes and the CD14(+)CD16(+)DR(++) proinflammatory monocytes that account for only 10% of all monocytes. We have studied TNF production in these two types of cells using three-color immunofluorescence and flow cytometry on whole peripheral blood samples stimulated with either LPS or with the bacterial lipopeptide S-(2,3-bis(palmitoyloxy)-(2-RS)-propyl)-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys(4)-OH,trihydrochloride (Pam3Cys). After stimulation with LPS the median fluorescence intensity for TNF protein was 3-fold higher in the proinflammatory monocytes when compared with the classical monocytes. After stimulation with Pam3Cys they almost exclusively responded showing 10-fold-higher levels of median fluorescence intensity for TNF protein. The median fluorescence intensity for Toll-like receptor 2 cell surface protein was found 2-fold higher on CD14(+)CD16(+)DR(++) monocytes, which may explain, in part, the higher Pam3Cys-induced TNF production by these cells. When analyzing secretion of TNF protein into the supernatant in PBMCs after depletion of CD16(+) monocytes we found a reduction of LPS-induced TNF by 28% but Pam3Cys-induced TNF was reduced by 64%. This indicates that the minor population of CD14(+)CD16(+) monocytes are major producers of TNF in human blood. | lld:pubmed |
| pubmed-article:11907116 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11907116 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11907116 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11907116 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11907116 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11907116 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11907116 | pubmed:author | pubmed-author:EspevikTerjeT | lld:pubmed |
| pubmed-article:11907116 | pubmed:author | pubmed-author:BelgeKai-UweK... | lld:pubmed |
| pubmed-article:11907116 | pubmed:author | pubmed-author:DayyaniFarshi... | lld:pubmed |
| pubmed-article:11907116 | pubmed:author | pubmed-author:HoreltAlexiaA | lld:pubmed |
| pubmed-article:11907116 | pubmed:author | pubmed-author:SiedlarMaciej... | lld:pubmed |
| pubmed-article:11907116 | pubmed:author | pubmed-author:Frankenberger... | lld:pubmed |
| pubmed-article:11907116 | pubmed:author | pubmed-author:Frankenberger... | lld:pubmed |
| pubmed-article:11907116 | pubmed:author | pubmed-author:Ziegler-Heitb... | lld:pubmed |
| pubmed-article:11907116 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11907116 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11907116 | pubmed:volume | 168 | lld:pubmed |
| pubmed-article:11907116 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11907116 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11907116 | pubmed:pagination | 3536-42 | lld:pubmed |
| pubmed-article:11907116 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11907116 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11907116 | pubmed:articleTitle | The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF. | lld:pubmed |
| pubmed-article:11907116 | pubmed:affiliation | Institute for Immunology, University of Muenchen, Germany. | lld:pubmed |
| pubmed-article:11907116 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11907116 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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