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pubmed-article:11902820pubmed:abstractTextThe cell cycle regulator cyclin D1 plays an important role in parathyroid tumourigenesis. The NciI polymorphism in exon 4 has recently been associated with early onset of hereditary nonpolyposis colorectal cancer and is a prognostic indicator of nonsmall cell lung cancer and squamous cell carcinomas. Furthermore, a limited study of 28 primary hyperparathyroidism (pHPT) patients displayed a tendency of NciI influence on HPT development. We hypothesized that the NciI polymorphism may relate to a risk of developing pHPT.lld:pubmed
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pubmed-article:11902820pubmed:articleTitleThe NeiI polymorphism in the cyclin D1 gene and sporadic primary hyperparathyroidism.lld:pubmed
pubmed-article:11902820pubmed:affiliationDepartment of Surgical Sciences, Uppsala University Hospital, Sweden. pamela.correa@kirurgi.uu.selld:pubmed
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