Source:http://linkedlifedata.com/resource/pubmed/id/11896424
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2002-3-15
|
| pubmed:abstractText |
Our study analyzes the mobilization of hematopoietic stem cells after two chemotherapeutic regimens in non-Hodgkin's lymphoma (NHL) patients. The study included 72 patients with NHL (42 follicular and 30 large cells). The mean age was 37 years (range 17-60). Sixty-four patients (88.9%) had stage III-IV disease. Forty-eight patients (66.7%) had bone marrow involvement. Systemic B symptoms were present in 42 patients (58.3%). Mobilization chemotherapy regimens were randomly assigned as DHAP in 38 patients (52.7%) or cyclophosphamide (CPM) (5 g/m(2)) in 34 (47.2%) and the results of 132 procedures were analyzed. At the time of PBSC mobilization, 46 patients (63.9%) were considered to be responsive (complete remission, partial remission or sensitive relapse) and 26 (36.1%) not responsive (refractory relapse or refractory to therapy). Pre-apheresis CD34+ blood cell count and number of previous chemotherapy treatments were used to predict the total number of CD34+ cells in the apheresis product. The mobilizing regimens (CPM or DHAP) were similar in achieving the threshold CD34+ cell yield, for optimal engraftment. Since DHAP was very effective as salvage treatment, we suggest using DHAP as a mobilizing regimen in patients with active residual lymphoma at the time of stem cell collection.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclophosphamide,
http://linkedlifedata.com/resource/pubmed/chemical/Cytarabine,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte Colony-Stimulating...
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0268-3369
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
285-90
|
| pubmed:dateRevised |
2006-4-24
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| pubmed:meshHeading |
pubmed-meshheading:11896424-Adolescent,
pubmed-meshheading:11896424-Adult,
pubmed-meshheading:11896424-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:11896424-Cisplatin,
pubmed-meshheading:11896424-Cyclophosphamide,
pubmed-meshheading:11896424-Cytarabine,
pubmed-meshheading:11896424-Dexamethasone,
pubmed-meshheading:11896424-Female,
pubmed-meshheading:11896424-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:11896424-Hematopoietic Stem Cell Mobilization,
pubmed-meshheading:11896424-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:11896424-Humans,
pubmed-meshheading:11896424-Leukocyte Count,
pubmed-meshheading:11896424-Lymphoma, Non-Hodgkin,
pubmed-meshheading:11896424-Male,
pubmed-meshheading:11896424-Middle Aged,
pubmed-meshheading:11896424-Prospective Studies,
pubmed-meshheading:11896424-Transplantation, Autologous
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Mobilization of peripheral blood stem cells with high-dose cyclophosphamide or the DHAP regimen plus G-CSF in non-Hodgkin's lymphoma.
|
| pubmed:affiliation |
Haematology, University of Bari, Medical School, Policlinico Bari, Italy.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|