Source:http://linkedlifedata.com/resource/pubmed/id/11886387
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2002-3-11
|
| pubmed:abstractText |
We describe an outbreak of vancomycin-resistant Enterococcus faecium (VRE) on the haematology ward of a Dutch university hospital. After the occurrence of three consecutive cases of bacteraemia with VRE, strains were genotyped and found to be identical. During the next 4 months an intensive surveillance programme identified 21 additional patients to be colonized with VRE, while two more patients developed bacteraemia. A case-control study was carried out to identify risk factors for VRE acquisition. In comparison with VRE-negative control patients (n=49), cases (n=24) had a longer stay on the ward during the year preceding the outbreak (25.8 versus 10.1 d, P=0.02), more cases with acute myeloid leukaemia [11 versus 4, odds ratio (OR) 9.5, 95% confidence interval (CI95) 2.4-32.2] and higher grades of mucositis (P=0.03). Logistic regression analysis identified antibiotic use within 1 month before admission (OR 13.0, CI95 2.1-80.5, P=0.006) and low albumin levels at baseline (OR 1.2, CI95 1.1-1.3, P=0.02) to be independent risk factors. Four patients with VRE-bacteraemia were successfully treated with quinupristin/dalfopristin (Synercid). Control of the outbreak was achieved by step-wise implementation of intensive infection control measures, which included the cohorting of patients, allocation of nurses and reinforcement of hand hygiene.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0007-1048
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
116
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
826-33
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:11886387-Adult,
pubmed-meshheading:11886387-Anti-Bacterial Agents,
pubmed-meshheading:11886387-Bacteremia,
pubmed-meshheading:11886387-Case-Control Studies,
pubmed-meshheading:11886387-Cross Infection,
pubmed-meshheading:11886387-Drug Therapy, Combination,
pubmed-meshheading:11886387-Enterococcus faecium,
pubmed-meshheading:11886387-Female,
pubmed-meshheading:11886387-Gram-Positive Bacterial Infections,
pubmed-meshheading:11886387-Hematology,
pubmed-meshheading:11886387-Hospital Departments,
pubmed-meshheading:11886387-Humans,
pubmed-meshheading:11886387-Infection Control,
pubmed-meshheading:11886387-Length of Stay,
pubmed-meshheading:11886387-Logistic Models,
pubmed-meshheading:11886387-Male,
pubmed-meshheading:11886387-Middle Aged,
pubmed-meshheading:11886387-Patient Isolation,
pubmed-meshheading:11886387-Risk Assessment,
pubmed-meshheading:11886387-Serum Albumin,
pubmed-meshheading:11886387-Vancomycin Resistance,
pubmed-meshheading:11886387-Virginiamycin
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Outbreak of vancomycin-resistant Enterococcus faecium in a haematology unit: risk factor assessment and successful control of the epidemic.
|
| pubmed:affiliation |
Department of Haematology, VU University Medical Centre, Amsterdam, the Netherlands. GJ.Timmers@VUMC.nl
|
| pubmed:publicationType |
Journal Article
|