Linked Life Data

11877905

Source:http://linkedlifedata.com/resource/pubmed/id/11877905

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-3-6
pubmed:abstractText
In a recent publication, we have shown a potent interaction between the cholinergic and GABAergic systems in regard to seizure generation and developed the pilocarpine(pilo)/picrotoxin(PTX) model, in which combined injections of these agents have induced status epilepticus (SE) in rats. Here we report on the chronic features of this new animal model of epilepsy. Adult male Wistar rats were systemically injected with solutions containing 150/0.5 mg kg-1, 75/1.5 mg kg-1 and 50/2.0 mg kg-1 (pilo dose/PTX dose). Six epileptic and six control animals were observed for 120-131 days for the occurrence of spontaneous recurrent seizures (SRS). Electroencephalographic, neuropathologic and behavioral analyses were subsequently performed. Following SE, the animals went through a latent period and, subsequently, towards a state of 'chronic' epilepsy, characterized by the emergence of SRS. Animals that received 150/0.5 mg kg-1 presented a relatively short latent period, partial events as their most common initial seizure manifestations and a considerable subsequent progression towards generalization. The group injected with 75/1.5 mg kg-1 presented an extensive period during which the majority of the animals exclusively developed partial seizures (50 days). Animals injected with 50/2.0 mg kg-1 presented an average latent period of over 100 days. Only few animals within this group developed SRS. Our EEG, neuropathological and ictal behavioral findings, in conjunction with the fact that SE was required for the posterior development of SRS, suggest that our model parallels a human TLE condition. Even though diverse TLE models have been described, the pilo/PTX model has as a major feature the intriguing occurrence of disparities among these three groups in the chronic period, although no differences could be observed during SE induction. Future experiments conducted in this sense, might lead to important results in regard to the elucidation of mechanisms of epileptogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0161-6412
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
199-209
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11877905-Acetylcholine, pubmed-meshheading:11877905-Action Potentials, pubmed-meshheading:11877905-Aggression, pubmed-meshheading:11877905-Animals, pubmed-meshheading:11877905-Behavior, Animal, pubmed-meshheading:11877905-Brain, pubmed-meshheading:11877905-Chronic Disease, pubmed-meshheading:11877905-Disease Models, Animal, pubmed-meshheading:11877905-Dose-Response Relationship, Drug, pubmed-meshheading:11877905-Electroencephalography, pubmed-meshheading:11877905-Epilepsy, pubmed-meshheading:11877905-Epilepsy, Temporal Lobe, pubmed-meshheading:11877905-GABA Antagonists, pubmed-meshheading:11877905-Male, pubmed-meshheading:11877905-Muscarinic Agonists, pubmed-meshheading:11877905-Nerve Degeneration, pubmed-meshheading:11877905-Neural Pathways, pubmed-meshheading:11877905-Neurons, pubmed-meshheading:11877905-Picrotoxin, pubmed-meshheading:11877905-Pilocarpine, pubmed-meshheading:11877905-Rats, pubmed-meshheading:11877905-Rats, Wistar, pubmed-meshheading:11877905-Reaction Time, pubmed-meshheading:11877905-Statistics as Topic, pubmed-meshheading:11877905-gamma-Aminobutyric Acid
pubmed:year
2002
pubmed:articleTitle
Spontaneous recurrent seizures and neuropathology in the chronic phase of the pilocarpine and picrotoxin model epilepsy.
pubmed:affiliation
Department of Physiology, UNIFESP-EPM, R. Botucatu 862, 04023-062 São Paulo-SP, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't