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rdf:type |
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lifeskim:mentions |
umls-concept:C0086597,
umls-concept:C0109317,
umls-concept:C0334227,
umls-concept:C0740457,
umls-concept:C0752312,
umls-concept:C1150579,
umls-concept:C1333340,
umls-concept:C1366882,
umls-concept:C1367307,
umls-concept:C1370600,
umls-concept:C1514485,
umls-concept:C1705767,
umls-concept:C1705791,
umls-concept:C1825791
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pubmed:issue |
3
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pubmed:dateCreated |
2002-2-18
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pubmed:abstractText |
Although interleukin-6 (IL-6) has been suggested to function as an autocrine growth factor in renal cell carcinoma (RCC), the underlying mechanism responsible for the IL-6-induced proliferation of RCC has not been defined. The aim of this study was to characterize the signaling cascades mediating IL-6-induced proliferation and to investigate the use of effective novel interventions to block the IL-6-induced autocrine growth of renal cancer cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/PD 98059,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrphostins,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-cyano-(3,4-dihydroxy)-N-benzyl...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
926-38
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11849447-Antibodies, Monoclonal,
pubmed-meshheading:11849447-Apoptosis,
pubmed-meshheading:11849447-Cell Division,
pubmed-meshheading:11849447-DNA-Binding Proteins,
pubmed-meshheading:11849447-Enzyme Activation,
pubmed-meshheading:11849447-Enzyme Inhibitors,
pubmed-meshheading:11849447-Flavonoids,
pubmed-meshheading:11849447-Humans,
pubmed-meshheading:11849447-Interleukin-6,
pubmed-meshheading:11849447-Intracellular Membranes,
pubmed-meshheading:11849447-Kidney Neoplasms,
pubmed-meshheading:11849447-MAP Kinase Kinase 1,
pubmed-meshheading:11849447-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:11849447-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11849447-Phosphorylation,
pubmed-meshheading:11849447-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11849447-Receptors, Interleukin-6,
pubmed-meshheading:11849447-STAT3 Transcription Factor,
pubmed-meshheading:11849447-Signal Transduction,
pubmed-meshheading:11849447-Trans-Activators,
pubmed-meshheading:11849447-Tumor Cells, Cultured,
pubmed-meshheading:11849447-Tyrosine,
pubmed-meshheading:11849447-Tyrphostins
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pubmed:year |
2002
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pubmed:articleTitle |
STAT3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P.
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pubmed:affiliation |
Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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