Source:http://linkedlifedata.com/resource/pubmed/id/11840313
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2002-2-12
|
| pubmed:abstractText |
The available data from preclinical and pharmacological studies on the role of gamma amino butyric acid (GABA) support the hypothesis that a dysfunction in brain GABAergic system activity contributes to the vulnerability to bipolar affective disorders (BPAD). Moreover, the localization of the alpha3 subunit GABA receptor GABRA3 gene on the Xq28, a region of interest in certain forms of bipolar illness, suggests that GABRA3 may be a candidate gene in BPAD. In the present study, we tested the genetic contribution of the GABRA3 dinucleotide polymorphism in a European multicentric case-control sample, matched for sex and ethnogeographical origin. Allele and genotype (in females) frequencies were compared in 185 BPAD patients and 370 controls. A significant increase of genotype 1-1 was observed in BPAD females compared to controls (P=0.0004). Furthermore, when considering recessivity of allele 1 (females with genotype 1-1 and males carrying allele 1), results were even more significant (P= 0.00002). Our findings suggest that the GABRA3 polymorphism may confer susceptibility to or may be in linkage disequilibrium with another gene involved in the genetic etiology of BPAD.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1359-4184
|
| pubmed:author |
pubmed-author:BlackwoodDD,
pubmed-author:Del-FaveroJJ,
pubmed-author:DikeosD GDG,
pubmed-author:FolnegovicVV,
pubmed-author:JakovljevicMM,
pubmed-author:KanevaRR,
pubmed-author:LilloLL,
pubmed-author:LordC PCP,
pubmed-author:MassatII,
pubmed-author:MendlewiczJJ,
pubmed-author:MilanovaVV,
pubmed-author:NoethenM MMM,
pubmed-author:OrucLL,
pubmed-author:PapadimitriouG NGN,
pubmed-author:RietschelMM,
pubmed-author:SerrettiAA,
pubmed-author:SmeraldiEE,
pubmed-author:SoueryDD,
pubmed-author:ThomsonMM,
pubmed-author:ValentaJJ,
pubmed-author:Van BroeckhovenCC
|
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
201-7
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11840313-Alleles,
pubmed-meshheading:11840313-Bipolar Disorder,
pubmed-meshheading:11840313-Case-Control Studies,
pubmed-meshheading:11840313-Europe,
pubmed-meshheading:11840313-Female,
pubmed-meshheading:11840313-Gene Frequency,
pubmed-meshheading:11840313-Genotype,
pubmed-meshheading:11840313-Humans,
pubmed-meshheading:11840313-Linkage Disequilibrium,
pubmed-meshheading:11840313-Male,
pubmed-meshheading:11840313-Polymorphism, Genetic,
pubmed-meshheading:11840313-Receptors, GABA,
pubmed-meshheading:11840313-X Chromosome
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study.
|
| pubmed:affiliation |
Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium. imassat@ulb.ac.be
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|