Linked Life Data

11836326

Source:http://linkedlifedata.com/resource/pubmed/id/11836326

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-2-11
pubmed:abstractText
It has been hypothesized that exposure to elevated levels of estrogens and IGFs before birth may increase breast cancer risk in female offspring. We examined whether the concentrations of estrone, E2, IGF-I, IGF-II, and IGF-binding protein-1 (IGFBP-1), -2, and -3 in umbilical cord blood plasma differed in female neonates of three racial/ethnic groups with contrasting breast cancer risk. The study included 57 Caucasian, 22 Hispanic, and 22 Asian-American subjects. Relative contribution of race/ethnicity to the analyte level variability was the largest for IGFBP-1 (P = 0.06). The only statistically significant (P < 0.05) mean difference was the lower IGFBP-3 levels in Asian than in Caucasian subjects. Adjusted mean levels of estrone and E2 for Asian subjects were 128% and 109% of the Caucasian means, respectively, whereas the Hispanic group showed lower means (85% and 84% of the Caucasian means). IGF-I, IGFBP-1, and IGFBP-3 showed lower adjusted means for both Hispanics and Asians compared with Caucasians. However, these differences were not statistically significant. In summary, we have shown that concentrations of estrogens, IGF-I, IGF-II, and IGFBPs are not different in cord blood samples from Caucasian, Hispanic, and Asian-American subjects. These data do not support a link between antenatal exposure to elevated levels of estrogens and IGFs and breast cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
810-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Concentrations of estrogens and IGFs in umbilical cord blood plasma: a comparison among Caucasian, Hispanic, and Asian-American females.
pubmed:affiliation
Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 54305-5405, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't