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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-1-21
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pubmed:abstractText |
Sorsby's fundus dystrophy (SFD) and age related macular degeneration (ARMD) are retinal diseases associated with a high level of accumulation of mutant and wild type TIMP-3, respectively, in Bruch's membrane. The pathogenic role of TIMP-3 in these diseases is uncertain, but causative mutations have been identified in the TIMP-3 gene of patients with SFD. Recent reports that TIMP-3 causes apoptosis in certain cell types and not in others prompted the authors to investigate whether TIMP-3 causes apoptosis in cultured retinal pigment epithelium (RPE) cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-10188875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-10476804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-1317548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-2477385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-2482957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-2622621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-5049457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-6193052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-7269283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-8132674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-8759363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-8806658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-9068940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-9243605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-9344510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-9502791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-9622064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-9642234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-9891890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11801512-9924344
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0007-1161
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
97-101
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11801512-Adenoviridae,
pubmed-meshheading:11801512-Apoptosis,
pubmed-meshheading:11801512-Blotting, Western,
pubmed-meshheading:11801512-Cell Count,
pubmed-meshheading:11801512-Cell Line,
pubmed-meshheading:11801512-Cell Survival,
pubmed-meshheading:11801512-Dose-Response Relationship, Drug,
pubmed-meshheading:11801512-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:11801512-Fundus Oculi,
pubmed-meshheading:11801512-Gene Therapy,
pubmed-meshheading:11801512-Humans,
pubmed-meshheading:11801512-Macular Degeneration,
pubmed-meshheading:11801512-Pigment Epithelium of Eye,
pubmed-meshheading:11801512-Retinal Diseases,
pubmed-meshheading:11801512-Tissue Inhibitor of Metalloproteinase-3,
pubmed-meshheading:11801512-Transduction, Genetic,
pubmed-meshheading:11801512-Transgenes,
pubmed-meshheading:11801512-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Adenovirus mediated gene delivery of tissue inhibitor of metalloproteinases-3 induces death in retinal pigment epithelial cells.
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pubmed:affiliation |
Institute of Ophthalmology, University of Bristol, Bristol Eye Hospital, Lower Maudlin Street Bristol BS1 2LX, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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