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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-1-8
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pubmed:abstractText |
Mature dendritic cells (DCs) are believed to induce T cell immunity, whereas immature DCs induce T cell tolerance. Here we describe that injections of DCs matured with tumor necrosis factor (TNF)-alpha (TNF/DCs) induce antigen-specific protection from experimental autoimmune encephalomyelitis (EAE) in mice. Maturation by TNF-alpha induced high levels of major histocompatibility complex class II and costimulatory molecules on DCs, but they remained weak producers of proinflammatory cytokines. One injection of such TNF/DCs pulsed with auto-antigenic peptide ameliorated the disease score of EAE. This could not be observed with immature DCs or DCs matured with lipopolysaccharide (LPS) plus anti-CD40. Three consecutive injections of peptide-pulsed TNF/DCs derived from wild-type led to the induction of peptide-specific predominantly interleukin (IL)-10-producing CD4(+) T cells and complete protection from EAE. Blocking of IL-10 in vivo could only partially restore the susceptibility to EAE, suggesting an important but not exclusive role of IL-10 for EAE prevention. Notably, the protection was peptide specific, as TNF/DCs pulsed with unrelated peptide could not prevent EAE. In conclusion, this study describes that stimulation by TNF-alpha results in incompletely matured DCs (semi-mature DCs) which induce peptide-specific IL-10-producing T cells in vivo and prevent EAE.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-10037236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-10432286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-10496317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-10520991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-10662786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-10662789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-10760792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-10795741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-10859329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-10940870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-10973276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-11046016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-11067871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-11106944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-11181695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-11208863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-11239447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-11254683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-11304549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-11390437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-11477409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-11520802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-11526392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-11536151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-11560993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-5968978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-7525841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-7875214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-8145053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-8402911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-8545887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-8830833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-9218570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-9366401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-9469423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11781361-9521319
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
195
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15-21
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11781361-Animals,
pubmed-meshheading:11781361-Autoimmunity,
pubmed-meshheading:11781361-Dendritic Cells,
pubmed-meshheading:11781361-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:11781361-Immune Tolerance,
pubmed-meshheading:11781361-Interleukin-10,
pubmed-meshheading:11781361-Mice,
pubmed-meshheading:11781361-Mice, Inbred C57BL,
pubmed-meshheading:11781361-Mice, Mutant Strains,
pubmed-meshheading:11781361-Myelin Proteins,
pubmed-meshheading:11781361-Myelin-Associated Glycoprotein,
pubmed-meshheading:11781361-Peptide Fragments,
pubmed-meshheading:11781361-T-Lymphocytes,
pubmed-meshheading:11781361-Tumor Necrosis Factor-alpha
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pubmed:year |
2002
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pubmed:articleTitle |
Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity.
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pubmed:affiliation |
Department of Dermatology, University of Erlangen, Erlangen 91052, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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