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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2001-12-10
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pubmed:abstractText |
Impaired polymorphonuclear neutrophil (PMN) functions were generally considered to be related to the onset of generalized aggressive periodontitis (GAgP). However, some research has indicated that the hyperreactivity of PMN seems to be involved in the inflammatory response of GAgP. The present study's main purpose was to provide more evidence about the role of PMN in the pathogenesis of GAgP by surveying PMN infiltration in gingiva and its relationship with the expression of their mediators including intercellular adhesion molecule-1 (ICAM-1), interleukin-8 (IL-8), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha). The inflammatory response in GAgP was also compared with that in adult periodontitis (AP) and periodontally healthy subjects. Since these PMN mediators were reported to be produced mainly by macrophages, the association between the expression of these PMN mediators and the distribution of macrophages was also investigated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD68 antigen, human,
http://linkedlifedata.com/resource/pubmed/chemical/Coloring Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-3492
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1545-53
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11759866-Adult,
pubmed-meshheading:11759866-Antigens, CD,
pubmed-meshheading:11759866-Antigens, Differentiation, Myelomonocytic,
pubmed-meshheading:11759866-Coloring Agents,
pubmed-meshheading:11759866-Connective Tissue,
pubmed-meshheading:11759866-Epithelium,
pubmed-meshheading:11759866-Female,
pubmed-meshheading:11759866-Fluorescent Dyes,
pubmed-meshheading:11759866-Gingiva,
pubmed-meshheading:11759866-Humans,
pubmed-meshheading:11759866-Immunohistochemistry,
pubmed-meshheading:11759866-In Situ Hybridization,
pubmed-meshheading:11759866-Inflammation Mediators,
pubmed-meshheading:11759866-Intercellular Adhesion Molecule-1,
pubmed-meshheading:11759866-Interleukin-1,
pubmed-meshheading:11759866-Interleukin-8,
pubmed-meshheading:11759866-Macrophages,
pubmed-meshheading:11759866-Male,
pubmed-meshheading:11759866-Neutrophil Infiltration,
pubmed-meshheading:11759866-Neutrophils,
pubmed-meshheading:11759866-Periodontal Pocket,
pubmed-meshheading:11759866-Periodontitis,
pubmed-meshheading:11759866-RNA, Messenger,
pubmed-meshheading:11759866-Tumor Necrosis Factor-alpha,
pubmed-meshheading:11759866-Up-Regulation
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pubmed:year |
2001
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pubmed:articleTitle |
Polymorphonuclear neutrophils and their mediators in gingival tissues from generalized aggressive periodontitis.
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pubmed:affiliation |
Department of Periodontology, School of Stomatology, Peking University, Beijing, China. liurk@pku.edu.cn
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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