| pubmed-article:11755918 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11755918 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11755918 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:11755918 | lifeskim:mentions | umls-concept:C0079633 | lld:lifeskim |
| pubmed-article:11755918 | lifeskim:mentions | umls-concept:C0033532 | lld:lifeskim |
| pubmed-article:11755918 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:11755918 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11755918 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:11755918 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11755918 | lifeskim:mentions | umls-concept:C0050218 | lld:lifeskim |
| pubmed-article:11755918 | lifeskim:mentions | umls-concept:C1312096 | lld:lifeskim |
| pubmed-article:11755918 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11755918 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11755918 | pubmed:dateCreated | 2001-12-28 | lld:pubmed |
| pubmed-article:11755918 | pubmed:abstractText | Interleukin-8 (IL-8) is one of cytokines detected at sites of inflammation and in macrophage-foam cells of atherosclerotic lesions. The expression of IL-8 gene can be induced in cholesterol loaded THP-1 macrophages by oxidized low density lipoprotein. We report for the first time that the expression of human IL-8 gene in THP-1 macrophages is upregulated in a time- and concentration-dependent manner by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2), which is a natural ligand for activation of peroxisome proliferator-activated receptor-gamma transcription factor. Studies to identify the signal transduction pathways involved showed that IL-8 upregulation-mediated by 15d-PGJ2 was markedly inhibited when the THP-1 macrophages were incubated with a highly selective and cell-permeable inhibitor of the mitogen-activated protein kinase (MAPK) signaling pathway, 2'-amino-3'-methoxyflavone (PD98059). This inhibition was concentration-dependent, suggesting that 15d-PGJ2 regulates the expression of IL-8 gene in THP-1 macrophages through a MAPK signaling pathway. In contrast, THP-1 macrophages when treated with pyrrolidine dithiocarbamate, an anti-oxidant and the selective inhibitor for nuclear factor kappaB, showed an enhanced 15d-PGJ2-mediated upregulation of IL-8 gene expression. The data presented in this report may contribute to unravel some of the mechanisms behind the inflammatory component of atherosclerosis. | lld:pubmed |
| pubmed-article:11755918 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11755918 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11755918 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11755918 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11755918 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11755918 | pubmed:issn | 0021-9150 | lld:pubmed |
| pubmed-article:11755918 | pubmed:author | pubmed-author:FuYuchangY | lld:pubmed |
| pubmed-article:11755918 | pubmed:author | pubmed-author:LuoNanlanN | lld:pubmed |
| pubmed-article:11755918 | pubmed:author | pubmed-author:Lopes-Virella... | lld:pubmed |
| pubmed-article:11755918 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11755918 | pubmed:volume | 160 | lld:pubmed |
| pubmed-article:11755918 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11755918 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11755918 | pubmed:pagination | 11-20 | lld:pubmed |
| pubmed-article:11755918 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11755918 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11755918 | pubmed:articleTitle | Upregulation of interleukin-8 expression by prostaglandin D2 metabolite 15-deoxy-delta12, 14 prostaglandin J2 (15d-PGJ2) in human THP-1 macrophages. | lld:pubmed |
| pubmed-article:11755918 | pubmed:affiliation | Division of Endocrinology, Diabetes and Medical Genetics, Department of Medicine, Room 520, Strom Thurmond Biomedical Center, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29403-5729, USA. fuy@musc.edu | lld:pubmed |
| pubmed-article:11755918 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11755918 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11755918 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11755918 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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