Source:http://linkedlifedata.com/resource/pubmed/id/11752121
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2001-12-25
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pubmed:abstractText |
In the previous study, we demonstrated that interleukin (IL)-18 up-regulated intercellular adhesion molecule-1 (ICAM-1) expression on monocytes in human peripheral blood mononuclear cells (PBMC) and that heterotypic interaction between monocytes/T or NK cells through ICAM-1/LFA-1 intensified the production of IL-12, interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) in PBMC. In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. The modulatory effects of histamine on ICAM-1 expression and cytokine production were all concentration dependently antagonized by famotidine but not by d-chlorpheniramine and thioperamide, and were mimicked by selective H(2)-receptor agonists but not by H(1)- and H(3)-receptor agonists, indicating the involvement of H(2)-receptors in histamine action. The inhibition of IL-18-induced IFN-gamma by histamine was ascribed to the strong inhibition of IL-12 production by histamine. Histamine thus operates the negative feedback mechanism against IL-18-activated cytokine cascade through the strong inhibitory effect on ICAM-1 expression and IL-12 production in monocytes, contributing to the formation of diverse pattern of cytokine activation from Th1 to Th2, depending on the monocyte/macrophage activation and cytokine environment.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Histamine H2
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-3565
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pubmed:author |
pubmed-author:AkagiTadaatsuT,
pubmed-author:ItohHideyukiH,
pubmed-author:IwagakiHiromiH,
pubmed-author:MoriShujiS,
pubmed-author:MorichikaToshihikoT,
pubmed-author:NishiboriMasahiroM,
pubmed-author:TakahashiHideo KohkaHK,
pubmed-author:TanakaNoriakiN,
pubmed-author:YokoyamaMinoriM,
pubmed-author:YoshidaAtsushiA,
pubmed-author:YoshinoTadashiT
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pubmed:issnType |
Print
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pubmed:volume |
300
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
227-35
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11752121-Cell Aggregation,
pubmed-meshheading:11752121-Cytokines,
pubmed-meshheading:11752121-Dose-Response Relationship, Drug,
pubmed-meshheading:11752121-Down-Regulation,
pubmed-meshheading:11752121-Flow Cytometry,
pubmed-meshheading:11752121-Histamine,
pubmed-meshheading:11752121-Histamine Agonists,
pubmed-meshheading:11752121-Humans,
pubmed-meshheading:11752121-Indicators and Reagents,
pubmed-meshheading:11752121-Intercellular Adhesion Molecule-1,
pubmed-meshheading:11752121-Interleukin-18,
pubmed-meshheading:11752121-Monocytes,
pubmed-meshheading:11752121-Receptors, Histamine H2
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pubmed:year |
2002
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pubmed:articleTitle |
Histamine regulation of interleukin-18-initiating cytokine cascade is associated with down-regulation of intercellular adhesion molecule-1 expression in human peripheral blood mononuclear cells.
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pubmed:affiliation |
Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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