| pubmed-article:11751884 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11751884 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:11751884 | lifeskim:mentions | umls-concept:C1367307 | lld:lifeskim |
| pubmed-article:11751884 | lifeskim:mentions | umls-concept:C0034786 | lld:lifeskim |
| pubmed-article:11751884 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:11751884 | lifeskim:mentions | umls-concept:C1370600 | lld:lifeskim |
| pubmed-article:11751884 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:11751884 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:11751884 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:11751884 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:11751884 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11751884 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:11751884 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:11751884 | pubmed:dateCreated | 2002-2-25 | lld:pubmed |
| pubmed-article:11751884 | pubmed:abstractText | The androgen receptor (AR) is a ligand-activated transcription factor that mediates the biological responses of androgens. However, non-androgenic pathways have also been shown to activate the AR. The mechanism of cross-talk between the interleukin-6 (IL-6) and AR signal transduction pathways was investigated in LNCaP human prostate cancer cells. IL-6 induced several androgen-response element-driven reporters that are dependent upon the AR, increased the phosphorylation of mitogen-activated protein kinase (MAPK), and activated the AR N-terminal domain (NTD). Inhibitors to MAPK and JAK decreased the IL-6-induced phosphorylation of MAPK and activation of the AR NTD. Immunoprecipitation and transactivation studies showed a direct interaction between amino acids 234-558 of the AR NTD and STAT3 following IL-6 treatment of LNCaP cells. These results demonstrate that activation of the human AR NTD by IL-6 was mediated through MAPK and STAT3 signal transduction pathways in LNCaP prostate cancer cells. | lld:pubmed |
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| pubmed-article:11751884 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11751884 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11751884 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11751884 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11751884 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11751884 | pubmed:author | pubmed-author:UedaTakeshiT | lld:pubmed |
| pubmed-article:11751884 | pubmed:author | pubmed-author:BruchovskyNic... | lld:pubmed |
| pubmed-article:11751884 | pubmed:author | pubmed-author:SadarMarianne... | lld:pubmed |
| pubmed-article:11751884 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11751884 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11751884 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:11751884 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11751884 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11751884 | pubmed:pagination | 7076-85 | lld:pubmed |
| pubmed-article:11751884 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11751884 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11751884 | pubmed:articleTitle | Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways. | lld:pubmed |
| pubmed-article:11751884 | pubmed:affiliation | Department of Cancer Endocrinology, British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada. | lld:pubmed |
| pubmed-article:11751884 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11751884 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11751884 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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