|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0021760,
umls-concept:C0034786,
umls-concept:C0086982,
umls-concept:C0752312,
umls-concept:C1367307,
umls-concept:C1370600,
umls-concept:C1514562,
umls-concept:C1879547,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2002-2-25
|
|
pubmed:abstractText |
The androgen receptor (AR) is a ligand-activated transcription factor that mediates the biological responses of androgens. However, non-androgenic pathways have also been shown to activate the AR. The mechanism of cross-talk between the interleukin-6 (IL-6) and AR signal transduction pathways was investigated in LNCaP human prostate cancer cells. IL-6 induced several androgen-response element-driven reporters that are dependent upon the AR, increased the phosphorylation of mitogen-activated protein kinase (MAPK), and activated the AR N-terminal domain (NTD). Inhibitors to MAPK and JAK decreased the IL-6-induced phosphorylation of MAPK and activation of the AR NTD. Immunoprecipitation and transactivation studies showed a direct interaction between amino acids 234-558 of the AR NTD and STAT3 following IL-6 treatment of LNCaP cells. These results demonstrate that activation of the human AR NTD by IL-6 was mediated through MAPK and STAT3 signal transduction pathways in LNCaP prostate cancer cells.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Anilides,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Forskolin,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/JAK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Androgen,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazolium Salts,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Tosyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/bicalutamide,
http://linkedlifedata.com/resource/pubmed/chemical/thiazolyl blue
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0021-9258
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
277
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
7076-85
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:11751884-Amino Acids,
pubmed-meshheading:11751884-Anilides,
pubmed-meshheading:11751884-Blotting, Northern,
pubmed-meshheading:11751884-DNA-Binding Proteins,
pubmed-meshheading:11751884-Dose-Response Relationship, Drug,
pubmed-meshheading:11751884-Enzyme Activation,
pubmed-meshheading:11751884-Forskolin,
pubmed-meshheading:11751884-Humans,
pubmed-meshheading:11751884-Immunoblotting,
pubmed-meshheading:11751884-Interleukin-6,
pubmed-meshheading:11751884-Janus Kinase 1,
pubmed-meshheading:11751884-Luciferases,
pubmed-meshheading:11751884-MAP Kinase Signaling System,
pubmed-meshheading:11751884-Male,
pubmed-meshheading:11751884-Models, Biological,
pubmed-meshheading:11751884-Nitriles,
pubmed-meshheading:11751884-Phosphorylation,
pubmed-meshheading:11751884-Plasmids,
pubmed-meshheading:11751884-Precipitin Tests,
pubmed-meshheading:11751884-Promoter Regions, Genetic,
pubmed-meshheading:11751884-Prostatic Neoplasms,
pubmed-meshheading:11751884-Protein Binding,
pubmed-meshheading:11751884-Protein Structure, Tertiary,
pubmed-meshheading:11751884-Protein-Tyrosine Kinases,
pubmed-meshheading:11751884-Receptors, Androgen,
pubmed-meshheading:11751884-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11751884-STAT3 Transcription Factor,
pubmed-meshheading:11751884-Signal Transduction,
pubmed-meshheading:11751884-Tetrazolium Salts,
pubmed-meshheading:11751884-Thiazoles,
pubmed-meshheading:11751884-Tosyl Compounds,
pubmed-meshheading:11751884-Trans-Activators,
pubmed-meshheading:11751884-Transcriptional Activation,
pubmed-meshheading:11751884-Transfection,
pubmed-meshheading:11751884-Tumor Cells, Cultured
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways.
|
|
pubmed:affiliation |
Department of Cancer Endocrinology, British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|
