Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2001-12-13
pubmed:abstractText
The flight muscles of Drosophila derive from myoblasts found on the third instar disc. We demonstrate that these myoblasts already show distinctive properties and examine how this diversity is generated. In the late larva, Vestigial and low levels of Cut are expressed in myoblasts that will contribute to the indirect flight muscles. Other myoblasts, which express high levels of Cut but no Vestigial, are required for the formation of the direct flight muscles. Vestigial and Cut expression are stabilized by a mutually repressive feedback loop. Vestigial expression begins in the embryo in a subset of adult myoblasts, and Wingless signaling is required later to maintain this expression. Thus, myoblasts are divided into identifiable populations, consistent with their allocation to different muscles, and ectodermal signals act to maintain these differences.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Cut protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Insect Hormones, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Twist Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 Protein, http://linkedlifedata.com/resource/pubmed/chemical/vestigial protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/wg protein, Drosophila
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1534-5807
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
829-39
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:11740944-Animals, pubmed-meshheading:11740944-Drosophila Proteins, pubmed-meshheading:11740944-Drosophila melanogaster, pubmed-meshheading:11740944-Ectoderm, pubmed-meshheading:11740944-Female, pubmed-meshheading:11740944-Genes, Reporter, pubmed-meshheading:11740944-Homeodomain Proteins, pubmed-meshheading:11740944-Insect Hormones, pubmed-meshheading:11740944-Male, pubmed-meshheading:11740944-Microscopy, Confocal, pubmed-meshheading:11740944-Morphogenesis, pubmed-meshheading:11740944-Muscles, pubmed-meshheading:11740944-Nerve Tissue Proteins, pubmed-meshheading:11740944-Nuclear Proteins, pubmed-meshheading:11740944-Phenotype, pubmed-meshheading:11740944-Proto-Oncogene Proteins, pubmed-meshheading:11740944-Recombinant Fusion Proteins, pubmed-meshheading:11740944-Repressor Proteins, pubmed-meshheading:11740944-Signal Transduction, pubmed-meshheading:11740944-Transcription Factors, pubmed-meshheading:11740944-Twist Transcription Factor, pubmed-meshheading:11740944-Wing, pubmed-meshheading:11740944-Wnt1 Protein
pubmed:year
2001
pubmed:articleTitle
Myoblast diversification and ectodermal signaling in Drosophila.
pubmed:affiliation
Centre for Developmental Genetics, Department of Biomedical Science, Western Bank, University of Sheffield Sheffield S10 2TN, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't