Linked Life Data

11726304

Source:http://linkedlifedata.com/resource/pubmed/id/11726304

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2001-11-29
pubmed:abstractText
In a cross-over study we investigated the effects of sildenafil (single doses of 25- or 50mg) on cardiovascular autonomic nervous system (ANS) function assessed by serial recordings of blood pressure, conventional 12-lead electrocardiograms and standardized, time-and frequency domain indices of heart rate variability (HRV) in 21 men with erectile dysfunction. More than half of these patients had multiple comorbidities. Sildenafil induced significant mean reductions from baseline in resting blood pressure, accompanied by a reflex increase in heart rate. There were no significant changes after administration of sildenafil in any other of the ANS function indices. These preliminary findings suggest that sildenafil does not significantly affect cardiac ANS function in patients with erectile dysfunction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0949-2321
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
459-64
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Cardiovascular effects of sildenafil citrate (Viagra): a naturalistic cross-over study.
pubmed:affiliation
Department of Biological Psychiatry and Neuroscience, Evangl. Clinics Gelsenkirchen, Ruhr-University of Bochum, Munckelstr. 27, D-45879 Gelsenkirchen, Germany. www.marcus.agelink@institute-of-biological-psychiatry.com
pubmed:publicationType
Journal Article, Clinical Trial