11709519

Source:http://linkedlifedata.com/resource/pubmed/id/11709519

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0015733, umls-concept:C0086418, umls-concept:C0227363, umls-concept:C0370003, umls-concept:C0443224, umls-concept:C0521375, umls-concept:C0678714, umls-concept:C1707455, umls-concept:C2347026
pubmed:issue	6
pubmed:dateCreated	2001-11-15
pubmed:abstractText	Deoxycholic acid (DCA), implicated in the pathogenesis of gall stones and colorectal cancer, is mainly formed by bacterial deconjugation (cholylglycine hydrolase (CGH)) and 7 alpha-dehydroxylation (7 alpha-dehydroxylase (7 alpha-DH)) of conjugated cholic acid (CA) in the caecum/proximal colon. Despite this, most previous studies of CGH and 7 alpha-DH have been in faeces rather than in caecal contents. In bacteria, CA increases 7 alpha-DH activity by substrate-enzyme induction but little is known about CA concentrations or CA/7 alpha-DH induction in the human colon.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2985108R
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/7 alpha-hydroxysteroid dehydrogenase, http://linkedlifedata.com/resource/pubmed/chemical/Amidohydrolases, http://linkedlifedata.com/resource/pubmed/chemical/Cholic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Deoxycholic Acid, http://linkedlifedata.com/resource/pubmed/chemical/Hydroxysteroid Dehydrogenases, http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases, http://linkedlifedata.com/resource/pubmed/chemical/Steroid Hydroxylases, http://linkedlifedata.com/resource/pubmed/chemical/choloylglycine hydrolase
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	0017-5749
pubmed:author	pubmed-author:DowlingR HRH, pubmed-author:FrenchGG, pubmed-author:HylemonP BPB, pubmed-author:MurphyG MGM, pubmed-author:ThomasL ALA, pubmed-author:VeyseyM JMJ
pubmed:issnType	Print
pubmed:volume	49
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	835-42
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:11709519-Aged, pubmed-meshheading:11709519-Amidohydrolases, pubmed-meshheading:11709519-Cecum, pubmed-meshheading:11709519-Cholelithiasis, pubmed-meshheading:11709519-Cholic Acid, pubmed-meshheading:11709519-Deoxycholic Acid, pubmed-meshheading:11709519-Feces, pubmed-meshheading:11709519-Female, pubmed-meshheading:11709519-Gastrointestinal Contents, pubmed-meshheading:11709519-Humans, pubmed-meshheading:11709519-Hydroxysteroid Dehydrogenases, pubmed-meshheading:11709519-Male, pubmed-meshheading:11709519-Middle Aged, pubmed-meshheading:11709519-Oxidoreductases, pubmed-meshheading:11709519-Steroid Hydroxylases
pubmed:year	2001
pubmed:articleTitle	Bile acid metabolism by fresh human colonic contents: a comparison of caecal versus faecal samples.
pubmed:affiliation	Gastroenterology Unit, Guy's Hospital Campus, UMDS, London, UK.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't