Source:http://linkedlifedata.com/resource/pubmed/id/11708929
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
24
|
| pubmed:dateCreated |
2001-11-15
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| pubmed:abstractText |
Of a series of new guanine base modified tricyclic analogues of acyclovir (ACV, 1) and ganciclovir (GCV, 2), derivatives of the 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purine system, evaluated for activity against herpes simplex virus type 1 and 2, several fluorescent analogues, 6-(4-MeOPh)-TACV (8), 7-Me-6-Ph-TACV (17), 6-(4-MeOPh)-TGCV (27), and 7-Me-6-Ph-TGCV (28), were obtained that showed similar potency and selectivity as the parent compounds. The activity was found to be strongly dependent on the nature and steric demands of the substituents in the 6 and/or 7 position.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0022-2623
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
22
|
| pubmed:volume |
44
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4284-7
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| pubmed:meshHeading |
pubmed-meshheading:11708929-Acyclovir,
pubmed-meshheading:11708929-Antiviral Agents,
pubmed-meshheading:11708929-Cell Line,
pubmed-meshheading:11708929-Cytopathogenic Effect, Viral,
pubmed-meshheading:11708929-Fluorescent Dyes,
pubmed-meshheading:11708929-Ganciclovir,
pubmed-meshheading:11708929-Herpesvirus 1, Human,
pubmed-meshheading:11708929-Herpesvirus 2, Human,
pubmed-meshheading:11708929-Structure-Activity Relationship
|
| pubmed:year |
2001
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| pubmed:articleTitle |
Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study.
|
| pubmed:affiliation |
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12-14, 61-704 Poznañ, Poland. bogolan@ibch.poznan.pl
|
| pubmed:publicationType |
Journal Article
|