Source:http://linkedlifedata.com/resource/pubmed/id/11706420
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2001-11-14
|
| pubmed:abstractText |
We investigated 100 cases of oral squamous cell carcinomas immunohistologically with respect to the expression of the epidermal growth factor receptor (EGFR) and the proliferating cell nuclear antigen (PCNA). The results were correlated with a new malignancy grading of the invasive tumour areas and the clinical outcome of the patients to estimate the individual prognosis. In conclusion, the amount of antigen expression of both antigens increases with the increasing grade of malignancy of the oral squamous cell carcinoma. Furthermore, there is a statistically significant correlation between the amount of antigen expression and the patient's prognosis. An overexpression of EGFR and PCNA is associated with a short survival of the patient. Both antigens detect relevant tumour biological parameters and are worthy factors in estimating the individual prognosis in patients suffering from oral squamous cell carcinomas.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0964-1955
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29B
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
273-7
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:11706420-Adult,
pubmed-meshheading:11706420-Carcinoma, Squamous Cell,
pubmed-meshheading:11706420-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:11706420-Humans,
pubmed-meshheading:11706420-Immunohistochemistry,
pubmed-meshheading:11706420-Mouth Neoplasms,
pubmed-meshheading:11706420-Neoplasm Invasiveness,
pubmed-meshheading:11706420-Neoplasm Staging,
pubmed-meshheading:11706420-Predictive Value of Tests,
pubmed-meshheading:11706420-Prognosis,
pubmed-meshheading:11706420-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:11706420-Prospective Studies,
pubmed-meshheading:11706420-Receptor, Epidermal Growth Factor,
pubmed-meshheading:11706420-Survival Analysis,
pubmed-meshheading:11706420-Treatment Outcome,
pubmed-meshheading:11706420-Tumor Markers, Biological
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
EGFR and PCNA expression in oral squamous cell carcinomas--a valuable tool in estimating the patient's prognosis.
|
| pubmed:affiliation |
Institute of Pathology, University of Mainz, Langenbeckstr. 1, D-6500 Mainz.
|
| pubmed:publicationType |
Journal Article
|