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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-10-23
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pubmed:abstractText |
TNF receptor-associated factor 1 (TRAF1) is a unique TRAF protein because it lacks a RING finger domain and is predominantly expressed in activated lymphocytes. To elucidate the function of TRAF1, we generated TRAF1-deficient mice. TRAF1(-/-) mice are viable and have normal lymphocyte development. TRAF1(-/-) T cells exhibit stronger than wild-type (WT) T cell proliferation to anti-CD3 mAb, which persisted in the presence of IL-2 or anti-CD28 antibodies. Activated TRAF1(-/-) T cells, but not TRAF1(+/+) T cells, responded to TNF by proliferation and activation of the NF-kappa B and AP-1 signaling pathways. This TNF effect was mediated by TNFR2 (p75) but not by TNFR1 (p55). Furthermore, skin from TRAF1(-/-) mice was hypersensitive to TNF-induced necrosis. These findings suggest that TRAF1 is a negative regulator of TNF signaling.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
647-57
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11672546-Animals,
pubmed-meshheading:11672546-Antibodies, Monoclonal,
pubmed-meshheading:11672546-Antigens, CD3,
pubmed-meshheading:11672546-Apoptosis,
pubmed-meshheading:11672546-B-Lymphocytes,
pubmed-meshheading:11672546-Cells, Cultured,
pubmed-meshheading:11672546-Immunoglobulins,
pubmed-meshheading:11672546-Kinetics,
pubmed-meshheading:11672546-Lymphocyte Activation,
pubmed-meshheading:11672546-Mice,
pubmed-meshheading:11672546-Mice, Knockout,
pubmed-meshheading:11672546-Necrosis,
pubmed-meshheading:11672546-Proteins,
pubmed-meshheading:11672546-Signal Transduction,
pubmed-meshheading:11672546-Skin Diseases,
pubmed-meshheading:11672546-Superantigens,
pubmed-meshheading:11672546-T-Lymphocytes,
pubmed-meshheading:11672546-TNF Receptor-Associated Factor 1,
pubmed-meshheading:11672546-Tumor Necrosis Factor-alpha
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pubmed:year |
2001
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pubmed:articleTitle |
TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice.
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pubmed:affiliation |
Division of Immunology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. tsitsikov_e@hub.tch.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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