pubmed:abstractText |
Plasminogen activator inhibitor type 1 (PAI-1) exerts antifibrinolytic and profibrotic activities. Inside the glomerulus, PAI-1 is mainly synthesized by mesangial cells. We hypothesized that thrombin, via its receptor protease activated receptor type 1 (PAR-1), present on the membrane of glomerular cells, is an important mediator of PAI-1 synthesis.
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pubmed:affiliation |
Département de Néphrologie A, Inserm U489, Association Claude Bernard, Hôpital Tenon, Paris, France.
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