rdf:type |
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lifeskim:mentions |
umls-concept:C0029433,
umls-concept:C0042071,
umls-concept:C0071216,
umls-concept:C0173695,
umls-concept:C0331858,
umls-concept:C0682323,
umls-concept:C0914341,
umls-concept:C1522670,
umls-concept:C1704640,
umls-concept:C1704675,
umls-concept:C1706515
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pubmed:issue |
10
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pubmed:dateCreated |
2001-10-12
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pubmed:abstractText |
The urokinase plasminogen activator receptor-associated protein/Endo180 (uPARAP/Endo180) is a newly discovered member of the macrophage mannose receptor family that was reported to interact with ligand-bound urokinase plasminogen activator receptor (uPAR), matrix metalloprotease-13 (MMP-13), and collagen V on the cell surface. We have determined the sites of expression of this novel receptor during murine postimplantation development. uPARAP/Endo180 was expressed in all tissues undergoing primary ossification, including the developing bones of the viscerocranium and calvarium that ossify intramembranously, and developing long bones undergoing endochondral ossification. uPARAP/Endo180 mRNA was expressed by both immature osteoblasts and by mature osteocalcin-producing osteoblasts-osteocytes, and was coexpressed with MMP-13. Interestingly, osteoblasts also expressed uPAR. Besides bone-forming tissues, uPARAP/Endo180 expression was detected only in a mesenchymal condensation of the midbrain and in the developing lungs. The data suggest a function of this novel protease receptor in bone development, possibly mediated through its interactions with uPAR, MMP-13, or collagen V.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagenases,
http://linkedlifedata.com/resource/pubmed/chemical/Endo180,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 13,
http://linkedlifedata.com/resource/pubmed/chemical/Mmp13 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Plaur protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Mitogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Urokinase Plasminogen...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0023-6837
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pubmed:author |
pubmed-author:BehrendtNN,
pubmed-author:Birkedal-HansenHH,
pubmed-author:BuggeT HTH,
pubmed-author:ChenX DXD,
pubmed-author:DanøKK,
pubmed-author:EngelholmL HLH,
pubmed-author:Lopez GarciaJ MJM,
pubmed-author:Lopez-OtinCC,
pubmed-author:LundL RLR,
pubmed-author:Netzel-ArnettSS,
pubmed-author:NielsenB SBS,
pubmed-author:SolbergHH,
pubmed-author:YoungM FMF
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1403-14
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11598153-Animals,
pubmed-meshheading:11598153-Bone and Bones,
pubmed-meshheading:11598153-Collagenases,
pubmed-meshheading:11598153-Embryonic and Fetal Development,
pubmed-meshheading:11598153-Female,
pubmed-meshheading:11598153-Immunohistochemistry,
pubmed-meshheading:11598153-Matrix Metalloproteinase 13,
pubmed-meshheading:11598153-Mice,
pubmed-meshheading:11598153-Osteogenesis,
pubmed-meshheading:11598153-Pregnancy,
pubmed-meshheading:11598153-Receptors, Cell Surface,
pubmed-meshheading:11598153-Receptors, Mitogen,
pubmed-meshheading:11598153-Receptors, Urokinase Plasminogen Activator
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pubmed:year |
2001
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pubmed:articleTitle |
The urokinase plasminogen activator receptor-associated protein/endo180 is coexpressed with its interaction partners urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesis.
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pubmed:affiliation |
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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