Linked Life Data

11583032

Source:http://linkedlifedata.com/resource/pubmed/id/11583032

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-10-3
pubmed:abstractText
Detection of tumor cell dissemination in solid tumor patients recently became essential to determine the prognosis of the disease and to monitor response to the therapy. Accurate detection of disseminated tumor cells in hematological samples requires tumor-specific target molecules, which allow sensitive and specific assays and, further, enable the quantification of tumor cells. Currently, numerous applications are in use, including immunological and molecular biological approaches. Theoretically, both ways are sensitive enough to detect less than one tumor cell in 1 million hematopoietic cells. With the improved sensitivity, however, the likelihood that unspecific events will be amplified is also increased. Moreover, biological and analytical variables may fundamentally influence the findings in a particular case. Basic methods, significant pitfalls and the most recent developments in this field are discussed in this overview.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0017-6559
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-109
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Detecting disseminated solid tumor cells in hematopoietic samples: methodological aspects.
pubmed:affiliation
CCRI, St Anna Kinderspital, Vienna, Austria.
pubmed:publicationType
Journal Article, Review