Linked Life Data

11580984

Source:http://linkedlifedata.com/resource/pubmed/id/11580984

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2001-10-2
pubmed:abstractText
The determinants of the prevalence of CD8(+) T cells in the inflamed myocardium of Trypanosoma cruzi-infected patients and experimental animals are undefined. Using C3H/He mice infected with the Colombiana strain of T. cruzi, we found that the distribution of CD4(+)/CD8(-) and CD4(-)/CD8(+) T cells in the myocardium mirrors the frequency of cells expressing the CD62L(Low)LFA-1(High)VLA-4(High) activation phenotype among CD4(+)/CD8(-) and CD4(-)/CD8(+ )peripheral blood T cells. Consistently, vascular cell adhesion molecule-1-positive endothelial cells and a fine fibronectin network surrounding VLA-4(+) mononuclear cells were found in the inflamed myocardium. Further, interferon gamma (IFN-gamma) and IFN-gamma-induced chemokines (RANTES, MIG and CRG-2/IP-10), as well as JE/MCP-1 and MIP1-alpha, were found to be the dominant cytokines expressed in situ during acute and chronic myocarditis elicited by T. cruzi. In contrast, interleukin 4 mRNA was only detected during the chronic phase. Altogether, the results indicate that the distribution of T-cell subsets in the myocardium of T. cruzi-infected mice reflects the particular profile of adhesion molecules acquired by most peripheral CD8(+) T lymphocytes and point to the possibility that multiple IFN-gamma-inducible molecules present in the inflamed tissue contribute to the establishment and maintenance of T. cruzi-induced myocarditis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1286-4579
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
971-84
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:11580984-Animals, pubmed-meshheading:11580984-CD8-Positive T-Lymphocytes, pubmed-meshheading:11580984-Cell Adhesion Molecules, pubmed-meshheading:11580984-Chagas Cardiomyopathy, pubmed-meshheading:11580984-Chemokines, pubmed-meshheading:11580984-Cytokines, pubmed-meshheading:11580984-Female, pubmed-meshheading:11580984-Immunophenotyping, pubmed-meshheading:11580984-Integrin alpha4beta1, pubmed-meshheading:11580984-Integrins, pubmed-meshheading:11580984-Interferon-gamma, pubmed-meshheading:11580984-L-Selectin, pubmed-meshheading:11580984-Lymphocyte Function-Associated Antigen-1, pubmed-meshheading:11580984-Mice, pubmed-meshheading:11580984-Mice, Inbred C3H, pubmed-meshheading:11580984-Myocardium, pubmed-meshheading:11580984-Parasitemia, pubmed-meshheading:11580984-Receptors, Antigen, T-Cell, alpha-beta, pubmed-meshheading:11580984-Receptors, Lymphocyte Homing
pubmed:year
2001
pubmed:articleTitle
Prevalence of CD8(+)alpha beta T cells in Trypanosoma cruzi-elicited myocarditis is associated with acquisition of CD62L(Low)LFA-1(High)VLA-4(High) activation phenotype and expression of IFN-gamma-inducible adhesion and chemoattractant molecules.
pubmed:affiliation
Laboratory of Autoimmunity and Immunoregulation, Department of Immunology, IOC-Fiocruz, Av. Brasil 4365, 21045-900, Rio de Janeiro, RJ, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't