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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2001-9-17
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pubmed:abstractText |
Clinical and experimental evidence indicates that the hepatitis C virus (HCV) E2 glycoprotein (HCV/E2) is the most promising candidate for the development of an effective anti-HCV vaccine. Identification of the human epitopes that are conserved among isolates and are able to elicit protective antibodies would constitute a significant step forward. This work describes the mapping of the B-cell epitopes present on the surface of HCV/E2, as recognized by the immune system during infection, by the analysis of the reciprocal interactions of a panel of human recombinant Fabs derived from an HCV-infected patient. Three unrelated epitopes recognized by antibodies with no neutralization-of-binding (NOB) activity were identified; a fourth, major epitope was defined as a clustering of minor epitopes recognized by Fabs endowed with strong NOB activity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-10462362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-10756048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-10764648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-10993933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-11044085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-1279801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-1280771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-1849654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-2496467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-2509915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-2523562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-6204335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-7509068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-7519785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-7526215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-7538251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-7545212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-7905553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-8173784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-8278393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-8700831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-8867614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-8971041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-9108620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-9236555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-9731577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-9755251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11559832-9847301
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-538X
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pubmed:author |
pubmed-author:BugliFF,
pubmed-author:BurioniRR,
pubmed-author:ClementiMM,
pubmed-author:Di CampliCC,
pubmed-author:FaddaGG,
pubmed-author:GabrielliAA,
pubmed-author:GasbarriniAA,
pubmed-author:GriecoAA,
pubmed-author:KangC YCY,
pubmed-author:ManciniNN,
pubmed-author:ManzinAA,
pubmed-author:VaraldoP EPE
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9986-90
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2001
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pubmed:articleTitle |
Mapping B-cell epitopes of hepatitis C virus E2 glycoprotein using human monoclonal antibodies from phage display libraries.
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pubmed:affiliation |
Istituti di Microbiologia, Facoltà di Medicina e Chirurgia, Università Cattolica del S. Cuore, 00168 Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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