Source:http://linkedlifedata.com/resource/pubmed/id/11545397
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
13
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pubmed:dateCreated |
2001-9-6
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pubmed:abstractText |
In this study, low concentrations of histamine2-receptor (H2-)antagonists were effected across a water plug, with separation taking place in a binary buffer comprising ethylene glycol and NaH2PO4 (pH 5.0), and detection at 214 nm. Liquid-liquid extraction with ethyl acetate- isopropanol is shown to provide extracts that are sufficiently clean. The calibration curves were linear over a concentration range of 0.1-2.00 microg/mL cimetidine, 0.2-5.0 microg/mL ranitidine-HCl, 0.3-5.0 microg/mL nizatidine, and 0.1-3.0 microg/mL famotidine. Mean recoveries were > 82%, while the intra- and interday relative standard deviations (RSDs) and relative errors (REs) were all < 13%. The method is sensitive with a detection limit of 3 ng/mL cimetidine, 30 ng/mL ranitidine HCl, 50 ng/mL nizatidine and 10 ng/mL famotidine (S/N = 3, electric-driven injection 90 s). This newly developed capillary electrophoresis (CE) method was applied for the determination of analytes extracted from plasma taken from a volunteer dosing a cimetidine, ranitidine, and nizatidine tablet simultaneously. These three H2-antagonists can be detected in real samples by this method, excluding the low dosing of famotidine tablet.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Buffers,
http://linkedlifedata.com/resource/pubmed/chemical/Cimetidine,
http://linkedlifedata.com/resource/pubmed/chemical/Ethylene Glycol,
http://linkedlifedata.com/resource/pubmed/chemical/Famotidine,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine H2 Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Nizatidine,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Ranitidine,
http://linkedlifedata.com/resource/pubmed/chemical/Water
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0173-0835
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2717-22
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11545397-Buffers,
pubmed-meshheading:11545397-Cimetidine,
pubmed-meshheading:11545397-Electric Conductivity,
pubmed-meshheading:11545397-Electrophoresis, Capillary,
pubmed-meshheading:11545397-Ethylene Glycol,
pubmed-meshheading:11545397-Famotidine,
pubmed-meshheading:11545397-Histamine H2 Antagonists,
pubmed-meshheading:11545397-Humans,
pubmed-meshheading:11545397-Nizatidine,
pubmed-meshheading:11545397-Phosphates,
pubmed-meshheading:11545397-Ranitidine,
pubmed-meshheading:11545397-Sensitivity and Specificity,
pubmed-meshheading:11545397-Time Factors,
pubmed-meshheading:11545397-Water
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pubmed:year |
2001
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pubmed:articleTitle |
Head-column field-amplified sample stacking in capillary electrophoresis for the determination of cimetidine, famotidine, nizatidine, and ranitidine-HCl in plasma.
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pubmed:affiliation |
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Taiwan. shmewu@kmu.edu.tw
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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