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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2001-9-6
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pubmed:abstractText |
Oral pseudomembranous candidiasis (OPC) was evaluated in 61 patients receiving head and neck radiotherapy (RT). Herpes simplex virus-1 (HSV-1) reactivation was also investigated in 14 patients. According to the agreed protocol, granulocyte-macrophage colony-stimulating factor (GM-CSF) mouthwash was administered in 46 patients with radiation-induced ulcers. Candidiasis was diagnosed in 31 patients. Candida albicans was the most frequent isolate. Multiple Candida species were isolated from the lesions of four patients. Concurrent candidiasis and radiation-induced ulcers were observed in 17 patients. Viral culture and the polymerase chain reaction disclosed the presence of HSV-1 in five patients. Twenty of the 46 patients, with initial mucositis grade II and grade III, completed RT with mucositis grade I, indicating a beneficial effect of GMCSF mouthwash, although further controlled studies are necessary to verify that. In conclusion, OPC was an important infection in patients undergoing radiotherapy. The role of HSV-1 in oral mucositis during head and neck radiotherapy needs additional study.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0904-2512
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pubmed:author |
pubmed-author:DardoufasKK,
pubmed-author:KolitsiGG,
pubmed-author:KoulouliasVV,
pubmed-author:KyprianouKK,
pubmed-author:LegakisN JNJ,
pubmed-author:MarkoulatosPP,
pubmed-author:Nicolatou-GalitisOO,
pubmed-author:PapanicolaouVV,
pubmed-author:PissakasGG,
pubmed-author:SkarleasCC,
pubmed-author:Sotiropoulou-LontouAA,
pubmed-author:VelegrakiAA
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
471-80
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11545238-Adenocarcinoma,
pubmed-meshheading:11545238-Adolescent,
pubmed-meshheading:11545238-Adult,
pubmed-meshheading:11545238-Aged,
pubmed-meshheading:11545238-Aged, 80 and over,
pubmed-meshheading:11545238-Candida,
pubmed-meshheading:11545238-Candida albicans,
pubmed-meshheading:11545238-Candidiasis, Oral,
pubmed-meshheading:11545238-Carcinoma,
pubmed-meshheading:11545238-Carcinoma, Squamous Cell,
pubmed-meshheading:11545238-Dose Fractionation,
pubmed-meshheading:11545238-Female,
pubmed-meshheading:11545238-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:11545238-Head and Neck Neoplasms,
pubmed-meshheading:11545238-Herpesvirus 1, Human,
pubmed-meshheading:11545238-Humans,
pubmed-meshheading:11545238-Lymphoma, Non-Hodgkin,
pubmed-meshheading:11545238-Male,
pubmed-meshheading:11545238-Middle Aged,
pubmed-meshheading:11545238-Mouthwashes,
pubmed-meshheading:11545238-Oral Ulcer,
pubmed-meshheading:11545238-Osteosarcoma,
pubmed-meshheading:11545238-Pilot Projects,
pubmed-meshheading:11545238-Polymerase Chain Reaction,
pubmed-meshheading:11545238-Radiation Injuries,
pubmed-meshheading:11545238-Stomatitis,
pubmed-meshheading:11545238-Stomatitis, Herpetic,
pubmed-meshheading:11545238-Treatment Outcome,
pubmed-meshheading:11545238-Virus Activation
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pubmed:year |
2001
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pubmed:articleTitle |
Oral pseudomembranous candidiasis, herpes simplex virus-1 infection, and oral mucositis in head and neck cancer patients receiving radiotherapy and granulocyte-macrophage colony-stimulating factor (GM-CSF) mouthwash.
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pubmed:affiliation |
Department of Oral Pathology and Surgery, School of Dentistry, University of Athens, Greece. nicolatou.galitis@mailcity.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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