| pubmed-article:11535341 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11535341 | lifeskim:mentions | umls-concept:C0035236 | lld:lifeskim |
| pubmed-article:11535341 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:11535341 | lifeskim:mentions | umls-concept:C0028948 | lld:lifeskim |
| pubmed-article:11535341 | lifeskim:mentions | umls-concept:C0042196 | lld:lifeskim |
| pubmed-article:11535341 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
| pubmed-article:11535341 | lifeskim:mentions | umls-concept:C0056912 | lld:lifeskim |
| pubmed-article:11535341 | lifeskim:mentions | umls-concept:C1518896 | lld:lifeskim |
| pubmed-article:11535341 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:11535341 | lifeskim:mentions | umls-concept:C0439133 | lld:lifeskim |
| pubmed-article:11535341 | lifeskim:mentions | umls-concept:C1522673 | lld:lifeskim |
| pubmed-article:11535341 | pubmed:issue | 32 | lld:pubmed |
| pubmed-article:11535341 | pubmed:dateCreated | 2001-9-5 | lld:pubmed |
| pubmed-article:11535341 | pubmed:abstractText | The feasibility of using oligodeoxynucleotides (ODN) containing unmethylated CpG motifs as parenteral adjuvants for subunit vaccines against RSV was tested in BALB/c mice. Compared with immunization with natural F protein adsorbed to aluminum hydroxide (F/AlOH) adjuvant alone, coadministration of F/AlOH with CpG ODN resulted in statistically significant increases in serum neutralization titers, an enhanced generation of splenic antigen-dependent killer cell precursors, and accelerated clearance of infectious virus from lungs 4 days after challenge. The statistically significant increases in serum IFNgamma and anti-F protein IgG2a titers, and significantly diminished pulmonary IL-5 and eosinophilia after challenge indicated that CpG ODN enhanced the ability of F/AlOH to elicit type 1 immune responses. F protein-specific serum IgE titers were also reduced. Further analysis of pulmonary inflammatory cells demonstrated an expansion of CD8(+) T cells, relative to the CD4(+) T cell compartment. The potency of CpG ODN was not adversely affected in gene knockout mice devoid of the p35 chain of the IL-12 heterodimer. Taken together, the results suggest a novel formulation for naïve recipients of F protein-based subunit vaccines that does not result in a type 2 phenotype. | lld:pubmed |
| pubmed-article:11535341 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11535341 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535341 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11535341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535341 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11535341 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11535341 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11535341 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:11535341 | pubmed:author | pubmed-author:SmithJ DJD | lld:pubmed |
| pubmed-article:11535341 | pubmed:author | pubmed-author:HancockG EGE | lld:pubmed |
| pubmed-article:11535341 | pubmed:author | pubmed-author:IbraghimovA... | lld:pubmed |
| pubmed-article:11535341 | pubmed:author | pubmed-author:HeersK MKM | lld:pubmed |
| pubmed-article:11535341 | pubmed:author | pubmed-author:ScheuerC ACA | lld:pubmed |
| pubmed-article:11535341 | pubmed:author | pubmed-author:PryharskiK... | lld:pubmed |
| pubmed-article:11535341 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11535341 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:11535341 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:11535341 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11535341 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11535341 | pubmed:pagination | 4874-82 | lld:pubmed |
| pubmed-article:11535341 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11535341 | pubmed:meshHeading | pubmed-meshheading:11535341... | lld:pubmed |
| pubmed-article:11535341 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11535341 | pubmed:articleTitle | CpG containing oligodeoxynucleotides are potent adjuvants for parenteral vaccination with the fusion (F) protein of respiratory syncytial virus (RSV). | lld:pubmed |
| pubmed-article:11535341 | pubmed:affiliation | Department of Immunology Research, Wyeth-Lederle Vaccines, 211 Bailey Road, West Henrietta, NY 14586, USA. hancocg@war.wyeth.com | lld:pubmed |
| pubmed-article:11535341 | pubmed:publicationType | Journal Article | lld:pubmed |
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