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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2001-8-29
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pubmed:abstractText |
The onset of pattern formation in the developing Drosophila retina begins with the initiation of the morphogenetic furrow, the leading edge of a wave of retinal development that transforms a uniform epithelium, the eye imaginal disc into a near crystalline array of ommatidial elements. The initiation of this wave of morphogenesis is under the control of the secreted morphogens Hedgehog (Hh), Decapentaplegic (Dpp) and Wingless (Wg). We show that the Epidermal Growth Factor Receptor and Notch signaling cascades are crucial components that are also required to initiate retinal development. We also show that the initiation of the morphogenetic furrow is the sum of two genetically separable processes: (1) the 'birth' of pattern formation at the posterior margin of the eye imaginal disc; and (2) the subsequent 'reincarnation' of retinal development across the epithelium.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hedgehog Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/dpp protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/hedgehog protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/notch protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/wg protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0950-1991
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
128
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2689-97
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11526075-Animals,
pubmed-meshheading:11526075-Drosophila Proteins,
pubmed-meshheading:11526075-Drosophila melanogaster,
pubmed-meshheading:11526075-Eye,
pubmed-meshheading:11526075-Hedgehog Proteins,
pubmed-meshheading:11526075-Insect Proteins,
pubmed-meshheading:11526075-Membrane Proteins,
pubmed-meshheading:11526075-Morphogenesis,
pubmed-meshheading:11526075-Proto-Oncogene Proteins,
pubmed-meshheading:11526075-Receptor, Epidermal Growth Factor,
pubmed-meshheading:11526075-Receptors, Notch,
pubmed-meshheading:11526075-Signal Transduction,
pubmed-meshheading:11526075-Wnt1 Protein
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pubmed:year |
2001
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pubmed:articleTitle |
The EGF receptor and notch signaling pathways control the initiation of the morphogenetic furrow during Drosophila eye development.
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pubmed:affiliation |
Department of Cell Biology, Emory University School of Medicine, 1648 Pierce Drive, Atlanta, GA 30322-3030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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