| pubmed-article:11511685 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11511685 | lifeskim:mentions | umls-concept:C0029408 | lld:lifeskim |
| pubmed-article:11511685 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11511685 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:11511685 | lifeskim:mentions | umls-concept:C0600251 | lld:lifeskim |
| pubmed-article:11511685 | lifeskim:mentions | umls-concept:C0007303 | lld:lifeskim |
| pubmed-article:11511685 | lifeskim:mentions | umls-concept:C0225415 | lld:lifeskim |
| pubmed-article:11511685 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:11511685 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:11511685 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:11511685 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:11511685 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:11511685 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:11511685 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:11511685 | pubmed:dateCreated | 2001-8-20 | lld:pubmed |
| pubmed-article:11511685 | pubmed:abstractText | The objective of our study was to determine the tissue distribution and localization of ADAM-10 protein in human and bovine cartilage and the changes it undergoes with cartilage degeneration seen in osteoarthritis (OA) and under the influence of interleukin-1 (IL-1). Human normal and OA articular cartilage and bovine nasal cartilage cultured in the presence of IL-1alpha were processed for histology and immunohistochemistry. ADAM-10 protein was extracted from human cartilage and analyzed by Western blotting using anti-ADAM-10 antibodies. Fluor S Image analyzer and Quantity One software program were applied to quantify the total amount of ADAM-10. ADAM-10 protein was detected in both human and bovine cartilage. The strongest immunostaining was found in the cytoplasm and/or cell membranes of the superficial and upper middle layer of normal adult human cartilage, in the clusters and fibrillated areas of OA cartilage, and in IL-1alpha-stimulated bovine nasal cartilage. The distribution of ADAM-10 protein in bovine nasal cartilage was dependent on the length of exposure to IL-1alpha and corresponded to the areas of proteoglycan depletion. By Western blotting analysis of human cartilage, ADAM-10 was primarily detected in the membrane-enriched fraction and its levels were increased in degenerated and OA cartilage compared to normal cartilage. The results of this study suggest that ADAM-10 might be an important factor associated with cartilage degenerative processes. (J Histochem Cytochem 49:1165-1176, 2001) | lld:pubmed |
| pubmed-article:11511685 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11511685 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11511685 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11511685 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11511685 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11511685 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11511685 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11511685 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11511685 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11511685 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11511685 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11511685 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11511685 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11511685 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11511685 | pubmed:issn | 0022-1554 | lld:pubmed |
| pubmed-article:11511685 | pubmed:author | pubmed-author:DeutschAA | lld:pubmed |
| pubmed-article:11511685 | pubmed:author | pubmed-author:TindalM HMH | lld:pubmed |
| pubmed-article:11511685 | pubmed:author | pubmed-author:ChubinskayaSS | lld:pubmed |
| pubmed-article:11511685 | pubmed:author | pubmed-author:MikhailRR | lld:pubmed |
| pubmed-article:11511685 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11511685 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:11511685 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11511685 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11511685 | pubmed:pagination | 1165-76 | lld:pubmed |
| pubmed-article:11511685 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11511685 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11511685 | pubmed:articleTitle | ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage. | lld:pubmed |
| pubmed-article:11511685 | pubmed:affiliation | Department of Biochemistry, Rush Medical College, Rush-Presbyterian-St Luke's Medical Center, 1653 W. Congress Parkway, Chicago, IL 60612, USA. | lld:pubmed |
| pubmed-article:11511685 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11511685 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11511685 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:102 | entrezgene:pubmed | pubmed-article:11511685 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11511685 | lld:pubmed |
