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rdf:type |
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lifeskim:mentions |
umls-concept:C0020966,
umls-concept:C0024518,
umls-concept:C0030956,
umls-concept:C0035820,
umls-concept:C0039195,
umls-concept:C0041484,
umls-concept:C0042900,
umls-concept:C0205369,
umls-concept:C0281722,
umls-concept:C0385723,
umls-concept:C0871261,
umls-concept:C1334510,
umls-concept:C1420066,
umls-concept:C1524063,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
2
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pubmed:dateCreated |
2001-8-20
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pubmed:abstractText |
Vitiligo is a common skin disease characterized by the presence of well circumscribed, depigmented, milky white macules devoid of identifiable melanocytes. Although the detection of circulating anti-melanocytic antibodies and of infiltrating lymphocytes at the margin of lesions supports the view that vitiligo is an autoimmune disorder, its etiology remains unknown. In particular, it is still a matter of debate whether the primary pathogenic role is exerted by humoral or cellular abnormal immune responses. In this study, the presence of specific cytotoxic T lymphocyte responses against the melanocyte differentiation antigens Melan-A/MART1, tyrosinase, and gp100 in vitiligo patients have been investigated by the use of major histocompatibility complex/peptide tetramers. High frequencies of circulating melanocyte-specific CD8+ T cells were found in all vitiligo patients analyzed. These cells exerted anti-melanocytic cytotoxic activity in vitro and expressed skin-homing capacity. In one patient melanocyte-specific cells were characterized by an exceptionally high avidity for their peptide/major histocompatibility complex ligand. These findings strongly suggest a role for cellular immunity in the pathogenesis of vitiligo and impact on the common mechanisms of self tolerance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A2 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/MART-1 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/MLANA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Monophenol Monooxygenase,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/SILV protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/gp100 Melanoma Antigen
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-202X
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pubmed:author |
pubmed-author:ArdigóMM,
pubmed-author:BadulliCC,
pubmed-author:BorroneCC,
pubmed-author:BrazzelliVV,
pubmed-author:CampanellaJJ,
pubmed-author:GarbelliSS,
pubmed-author:GiachinoCC,
pubmed-author:LantelmeEE,
pubmed-author:MantovaniSS,
pubmed-author:MartinettiMM,
pubmed-author:NeckerAA,
pubmed-author:PalermoBB
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pubmed:issnType |
Print
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
326-32
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11511311-Antigens, Neoplasm,
pubmed-meshheading:11511311-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11511311-Cell Differentiation,
pubmed-meshheading:11511311-Cell Line,
pubmed-meshheading:11511311-Female,
pubmed-meshheading:11511311-Flow Cytometry,
pubmed-meshheading:11511311-HLA-A2 Antigen,
pubmed-meshheading:11511311-Humans,
pubmed-meshheading:11511311-Immunity, Cellular,
pubmed-meshheading:11511311-MART-1 Antigen,
pubmed-meshheading:11511311-Male,
pubmed-meshheading:11511311-Melanocytes,
pubmed-meshheading:11511311-Membrane Glycoproteins,
pubmed-meshheading:11511311-Monophenol Monooxygenase,
pubmed-meshheading:11511311-Neoplasm Proteins,
pubmed-meshheading:11511311-Peptide Fragments,
pubmed-meshheading:11511311-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:11511311-Vitiligo,
pubmed-meshheading:11511311-gp100 Melanoma Antigen
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pubmed:year |
2001
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pubmed:articleTitle |
Specific cytotoxic T lymphocyte responses against Melan-A/MART1, tyrosinase and gp100 in vitiligo by the use of major histocompatibility complex/peptide tetramers: the role of cellular immunity in the etiopathogenesis of vitiligo.
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pubmed:affiliation |
Experimental Immunology, IRCCS Maugeri Foundation, Pavia, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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