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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-8-16
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pubmed:abstractText |
c-Jun N-terminal kinase (JNK) is one of the several main MAP kinase groups identified in mammals. Original studies by use of Jurkat T cells implicated JNK in T cell activation and interleukin (IL-2) expression. Recent advances using mouse genetic approaches have revealed novel functions of this pathway in primary mouse T cells. JNK is not essential for T-cell activation; instead, it is required for helper T differentiation into effector cells and their cytokine production. In this review, we summarize these advances in understanding the expression, function, and regulation of the JNK pathway in T-lymphocyte activation and differentiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 4,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 7,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MAP2K7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Map2k4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Map2k7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0271-9142
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
253-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11506194-Animals,
pubmed-meshheading:11506194-Cell Differentiation,
pubmed-meshheading:11506194-Enzyme Activation,
pubmed-meshheading:11506194-Humans,
pubmed-meshheading:11506194-Interferon-gamma,
pubmed-meshheading:11506194-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:11506194-Lymphocyte Activation,
pubmed-meshheading:11506194-MAP Kinase Kinase 4,
pubmed-meshheading:11506194-MAP Kinase Kinase 7,
pubmed-meshheading:11506194-Mice,
pubmed-meshheading:11506194-Mitogen-Activated Protein Kinase 8,
pubmed-meshheading:11506194-Mitogen-Activated Protein Kinase 9,
pubmed-meshheading:11506194-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:11506194-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11506194-Models, Biological,
pubmed-meshheading:11506194-Signal Transduction,
pubmed-meshheading:11506194-T-Lymphocytes,
pubmed-meshheading:11506194-Th1 Cells
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pubmed:year |
2001
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pubmed:articleTitle |
Signaling by the JNK group of MAP kinases. c-jun N-terminal Kinase.
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pubmed:affiliation |
Section of Immunobiology, Yale University School of Medicine and Howard Hughes, Medical Institute, New Haven, Connecticut 06520, USA.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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