|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0035647,
umls-concept:C0162714,
umls-concept:C0210994,
umls-concept:C0242643,
umls-concept:C0243144,
umls-concept:C0392756,
umls-concept:C0596902,
umls-concept:C0879392,
umls-concept:C0919458,
umls-concept:C0949670,
umls-concept:C1332714,
umls-concept:C1704873,
umls-concept:C2266986
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|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2001-8-15
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|
pubmed:abstractText |
The multidrug transporters P-glycoprotein (P-gp) and MRP1 are functionally expressed in several subclasses of lymphocytes. HIV-1 protease inhibitors interact with both; consequently the transporters could reduce the local concentration of HIV-1 protease inhibitors and, thus, influence the selection of viral mutants.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0269-9370
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
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pubmed:day |
27
|
|
pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1353-8
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11504956-ATP-Binding Cassette Transporters,
pubmed-meshheading:11504956-Biological Transport,
pubmed-meshheading:11504956-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11504956-Cell Line,
pubmed-meshheading:11504956-Drug Resistance, Microbial,
pubmed-meshheading:11504956-Drug Resistance, Multiple,
pubmed-meshheading:11504956-HIV Protease Inhibitors,
pubmed-meshheading:11504956-Humans,
pubmed-meshheading:11504956-Indinavir,
pubmed-meshheading:11504956-Multidrug Resistance-Associated Proteins,
pubmed-meshheading:11504956-Nelfinavir,
pubmed-meshheading:11504956-P-Glycoprotein,
pubmed-meshheading:11504956-Ritonavir,
pubmed-meshheading:11504956-Saquinavir
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|
pubmed:year |
2001
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|
pubmed:articleTitle |
P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance?
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pubmed:affiliation |
Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
