|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2001-7-13
|
|
pubmed:abstractText |
Osteonecrosis of the femoral head frequently leads to collapse of the articular cartilage and to disabling osteoarthritis, which ultimately may necessitate joint arthroplasty. One treatment method that has had moderate success is the so-called trapdoor approach, which involves excavation of diseased (necrotic) bone followed by bone-grafting. Augmentation of this procedure with various growth and differentiation factors may improve the outcome. We developed a canine model that mimics the clinical situation with trapdoor bone-grafting. The objective of this study was to evaluate the effect of the addition of osteogenic protein-1 on healing following the trapdoor procedure with strut-autografting.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0021-9355
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
83-A
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1013-22
|
|
pubmed:dateRevised |
2010-10-25
|
|
pubmed:meshHeading |
pubmed-meshheading:11451970-Analysis of Variance,
pubmed-meshheading:11451970-Animals,
pubmed-meshheading:11451970-Biomechanics,
pubmed-meshheading:11451970-Bone Morphogenetic Protein 7,
pubmed-meshheading:11451970-Bone Morphogenetic Proteins,
pubmed-meshheading:11451970-Bone Transplantation,
pubmed-meshheading:11451970-Combined Modality Therapy,
pubmed-meshheading:11451970-Disease Models, Animal,
pubmed-meshheading:11451970-Dogs,
pubmed-meshheading:11451970-Female,
pubmed-meshheading:11451970-Femur Head Necrosis,
pubmed-meshheading:11451970-Follow-Up Studies,
pubmed-meshheading:11451970-Male,
pubmed-meshheading:11451970-Random Allocation,
pubmed-meshheading:11451970-Range of Motion, Articular,
pubmed-meshheading:11451970-Reference Values,
pubmed-meshheading:11451970-Sensitivity and Specificity,
pubmed-meshheading:11451970-Tissue and Organ Harvesting,
pubmed-meshheading:11451970-Transforming Growth Factor beta,
pubmed-meshheading:11451970-Transplantation, Autologous,
pubmed-meshheading:11451970-Treatment Outcome
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Strut-autografting with and without osteogenic protein-1 : a preliminary study of a canine femoral head defect model.
|
|
pubmed:affiliation |
Department of Orthopaedics Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21239, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
