Linked Life Data

11444043

Source:http://linkedlifedata.com/resource/pubmed/id/11444043

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2001-7-10
pubmed:abstractText
In the imaginal discs of Drosophila, contact-dependent cell interactions are important both for promoting cell proliferation and for limiting it at the end of the growth period. However, recent work indicates that diffusible growth factors are also important in regulating growth and proliferation. We have identified a family of five imaginal disc growth factors (IDGFs) by purifying mitogenic proteins that accumulate in conditioned medium during culture of imaginal disc cell lines. These proteins cooperate with insulin to stimulate not only proliferation, but also polarization and motility of imaginal disc cells. They are produced by the fat body and are probably active on a variety of peripheral tissues. The IDGFs are structurally related to chitinases, but they show an amino acid substitution that is known to abrogate catalytic activity and to transform chitinases into lectins. We suggest that these proteins act as endogenous mitogenic lectins and mediate nutritional effects on tissue growth, possibly by interacting with the insulin receptor pathway. Glycoproteins similar to the IDGFs are found in mammals and may constitute a novel class of growth factors and/or inflammatory cytokines.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1528-2511
pubmed:author
pubmed:issnType
Print
pubmed:volume
237
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
182-94; discussion 194-202
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Growth factors controlling imaginal disc growth in Drosophila.
pubmed:affiliation
Developmental Biology Center, University of California Irvine, Irvine, CA 92697, USA.
pubmed:publicationType
Journal Article, Review