|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2001-7-3
|
|
pubmed:abstractText |
1,25-Dihydroxyvitamin D(3) is mainly synthesized by renal proximal tubular cells. More recently, it has been shown to affect cell growth and TGF-beta(1) synthesis in glomerular and tubular renal cells in vitro, and to prevent glomerulosclerosis in vivo in subtotally nephrectomized rats. The mechanisms involved have not been fully identified. We asked whether 1,25-vitamin D(3) might interact with additional immunoregulatory functions of renal cells by studying its effects on the expression of the cellular adhesion molecules ICAM-1 (CD54) and VCAM-1 (CD106) in human proximal tubular cells in vitro (HK-2 cells).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1420-4096
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
24
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
92-8
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:11435740-Calcifediol,
pubmed-meshheading:11435740-Calcitriol,
pubmed-meshheading:11435740-Cell Adhesion,
pubmed-meshheading:11435740-Cell Line, Transformed,
pubmed-meshheading:11435740-Culture Media, Serum-Free,
pubmed-meshheading:11435740-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:11435740-Flow Cytometry,
pubmed-meshheading:11435740-Gene Expression Regulation,
pubmed-meshheading:11435740-Humans,
pubmed-meshheading:11435740-Intercellular Adhesion Molecule-1,
pubmed-meshheading:11435740-Interferon-gamma,
pubmed-meshheading:11435740-Recombinant Proteins,
pubmed-meshheading:11435740-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11435740-Tumor Necrosis Factor-alpha,
pubmed-meshheading:11435740-Vascular Cell Adhesion Molecule-1
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Suppression of ICAM-1 expression in renal proximal tubular cells by 1,25-dihydroxyvitamin D3.
|
|
pubmed:affiliation |
Department of Internal Medicine, Division of Nephrology, University Hospital, Zürich, Switzerland. Dialyse-VS.DrWeinreich@T-online.de
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
