| pubmed-article:11394884 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11394884 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:11394884 | lifeskim:mentions | umls-concept:C0042071 | lld:lifeskim |
| pubmed-article:11394884 | lifeskim:mentions | umls-concept:C0332255 | lld:lifeskim |
| pubmed-article:11394884 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:11394884 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11394884 | pubmed:dateCreated | 2001-6-7 | lld:pubmed |
| pubmed-article:11394884 | pubmed:abstractText | CD8+ T lymphocytes have been shown to produce unidentified soluble factors active in suppressing HIV-1 replication. In this study, we purified an HIV-1 suppressing activity from the culture supernatant of an immortalized CD8+ T cell clone, derived from an HIV-1 infected long-term nonprogressor, and identified this activity as the amino-terminal fragment (ATF) of urokinase-type plasminogen activator (uPA). ATF is catalytically inactive, but suppresses the release of viral particles from the HIV-1 infected cell lines via binding to its receptor CD87. In contrast, cell proliferation and the secretion of an HIV-1 LTR driven reporter gene product were not affected by ATF. These findings suggest that ATF may inhibit the assembly and budding of HIV-1, which provides a novel therapeutic strategy for AIDS. | lld:pubmed |
| pubmed-article:11394884 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11394884 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11394884 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11394884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11394884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11394884 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11394884 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11394884 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:11394884 | pubmed:author | pubmed-author:TaniguchiKK | lld:pubmed |
| pubmed-article:11394884 | pubmed:author | pubmed-author:WadaMM | lld:pubmed |
| pubmed-article:11394884 | pubmed:author | pubmed-author:TsuchieHH | lld:pubmed |
| pubmed-article:11394884 | pubmed:author | pubmed-author:KogaJJ | lld:pubmed |
| pubmed-article:11394884 | pubmed:author | pubmed-author:ShironoHH | lld:pubmed |
| pubmed-article:11394884 | pubmed:author | pubmed-author:WadaN ANA | lld:pubmed |
| pubmed-article:11394884 | pubmed:copyrightInfo | Copyright 2001 Academic Press. | lld:pubmed |
| pubmed-article:11394884 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11394884 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:11394884 | pubmed:volume | 284 | lld:pubmed |
| pubmed-article:11394884 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11394884 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11394884 | pubmed:pagination | 346-51 | lld:pubmed |
| pubmed-article:11394884 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11394884 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11394884 | pubmed:articleTitle | Amino-terminal fragment of urokinase-type plasminogen activator inhibits HIV-1 replication. | lld:pubmed |
| pubmed-article:11394884 | pubmed:affiliation | Laboratories for Bioengineering and Research, JCR Pharmaceuticals Company, Ltd., 2-2-10 Murotani, Nishi-ku, Kobe, 651-2241, Japan. wada-m@jcrpharm.co.jp | lld:pubmed |
| pubmed-article:11394884 | pubmed:publicationType | Journal Article | lld:pubmed |
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