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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-6-7
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pubmed:abstractText |
CD8+ T lymphocytes have been shown to produce unidentified soluble factors active in suppressing HIV-1 replication. In this study, we purified an HIV-1 suppressing activity from the culture supernatant of an immortalized CD8+ T cell clone, derived from an HIV-1 infected long-term nonprogressor, and identified this activity as the amino-terminal fragment (ATF) of urokinase-type plasminogen activator (uPA). ATF is catalytically inactive, but suppresses the release of viral particles from the HIV-1 infected cell lines via binding to its receptor CD87. In contrast, cell proliferation and the secretion of an HIV-1 LTR driven reporter gene product were not affected by ATF. These findings suggest that ATF may inhibit the assembly and budding of HIV-1, which provides a novel therapeutic strategy for AIDS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, gag,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/PLAUR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Urokinase Plasminogen...,
http://linkedlifedata.com/resource/pubmed/chemical/Urokinase-Type Plasminogen Activator,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/gag Gene Products, Human...,
http://linkedlifedata.com/resource/pubmed/chemical/p17 protein, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
284
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
346-51
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11394884-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11394884-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11394884-Cell Division,
pubmed-meshheading:11394884-Cells, Cultured,
pubmed-meshheading:11394884-Clone Cells,
pubmed-meshheading:11394884-Coculture Techniques,
pubmed-meshheading:11394884-Culture Media, Conditioned,
pubmed-meshheading:11394884-Dose-Response Relationship, Drug,
pubmed-meshheading:11394884-Gene Products, gag,
pubmed-meshheading:11394884-Genes, Reporter,
pubmed-meshheading:11394884-HIV Antigens,
pubmed-meshheading:11394884-HIV Infections,
pubmed-meshheading:11394884-HIV Long Terminal Repeat,
pubmed-meshheading:11394884-HIV-1,
pubmed-meshheading:11394884-Humans,
pubmed-meshheading:11394884-Peptide Fragments,
pubmed-meshheading:11394884-Receptors, Cell Surface,
pubmed-meshheading:11394884-Receptors, Urokinase Plasminogen Activator,
pubmed-meshheading:11394884-Sarcoma, Kaposi,
pubmed-meshheading:11394884-Survivors,
pubmed-meshheading:11394884-Transfection,
pubmed-meshheading:11394884-Urokinase-Type Plasminogen Activator,
pubmed-meshheading:11394884-Viral Proteins,
pubmed-meshheading:11394884-Virus Replication,
pubmed-meshheading:11394884-gag Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2001
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pubmed:articleTitle |
Amino-terminal fragment of urokinase-type plasminogen activator inhibits HIV-1 replication.
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pubmed:affiliation |
Laboratories for Bioengineering and Research, JCR Pharmaceuticals Company, Ltd., 2-2-10 Murotani, Nishi-ku, Kobe, 651-2241, Japan. wada-m@jcrpharm.co.jp
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pubmed:publicationType |
Journal Article
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