Source:http://linkedlifedata.com/resource/pubmed/id/11390487
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2001-6-6
|
| pubmed:abstractText |
Mice deficient in CD18, which lack all four CD11 integrins, have leukocytosis and increased susceptibility to bacterial infection. To determine the effect of deficiencies in LFA-1 (CD11a/CD18) or Mac-1 (CD11b/CD18) on host defense against systemic bacterial infection, knockout mice were inoculated i.p. with Streptococcus pneumoniae. Increased mortality occurred in both LFA-1(-/-) (15 of 17 vs 13 of 35 in wild type (WT), p < 0.01) and Mac-1(-/-) (17 of 34 vs 6 of 25, p < 0.01) mice. All deaths in LFA-1(-/-) mice occurred after 72 h, whereas most deaths in Mac-1(-/-) mice occurred within 24-48 h. At 24 h, 21 of 27 Mac-1(-/-) mice were bacteremic, vs 15 of 25 WT (p = 0.05); no difference was observed between LFA-1(-/-) and WT. Increased bacteria were recovered from Mac-1(-/-) spleens at 2 h (p = 0.03) and 6 h (p = 0.002) and from livers (p = 0.001) by 6 h. No difference was observed at 2 h in LFA-1(-/-) mice, but by 6 h increased bacteria were recovered from spleens (p = 0.008) and livers (p = 0.04). Baseline and peak leukocyte counts were similar between Mac-1(-/-) and WT, but elevated in LFA-1(-/-). At 8 h, peritoneal neutrophils were increased in Mac-1(-/-), but not significantly different in LFA-1(-/-). Histopathologically, at 24 h Mac-1(-/-) animals had bacteremia and lymphoid depletion, consistent with sepsis. LFA-1(-/-) mice had increased incidence of otitis media and meningitis/encephalitis vs WT at 72 and 96 h. Both Mac-1 and LFA-1 play important but distinct roles in host defense to S. pneumoniae.
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| pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AI19031,
http://linkedlifedata.com/resource/pubmed/grant/ES06091,
http://linkedlifedata.com/resource/pubmed/grant/HL-42550,
http://linkedlifedata.com/resource/pubmed/grant/R01-HL62243-01,
http://linkedlifedata.com/resource/pubmed/grant/T32 HL07812-0181
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
166
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
7362-9
|
| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11390487-Animals,
pubmed-meshheading:11390487-Ascitic Fluid,
pubmed-meshheading:11390487-Bacteremia,
pubmed-meshheading:11390487-Humans,
pubmed-meshheading:11390487-Leukocyte Count,
pubmed-meshheading:11390487-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:11390487-Macrophage-1 Antigen,
pubmed-meshheading:11390487-Meningitis, Bacterial,
pubmed-meshheading:11390487-Meningitis, Pneumococcal,
pubmed-meshheading:11390487-Meningoencephalitis,
pubmed-meshheading:11390487-Mice,
pubmed-meshheading:11390487-Mice, Inbred C57BL,
pubmed-meshheading:11390487-Mice, Knockout,
pubmed-meshheading:11390487-Organ Culture Techniques,
pubmed-meshheading:11390487-Otitis Media,
pubmed-meshheading:11390487-Pneumococcal Infections,
pubmed-meshheading:11390487-Streptococcus pneumoniae,
pubmed-meshheading:11390487-Survival Analysis
|
| pubmed:year |
2001
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| pubmed:articleTitle |
The differential roles of LFA-1 and Mac-1 in host defense against systemic infection with Streptococcus pneumoniae.
|
| pubmed:affiliation |
Section of Atherosclerosis, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|