Source:http://linkedlifedata.com/resource/pubmed/id/11389956
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3-4
|
| pubmed:dateCreated |
2001-6-6
|
| pubmed:databankReference | |
| pubmed:abstractText |
Interleukin-18 (IL-18) is a cytokine with potent interferon-gamma-inducing activity, and plays an important biologic role in the enhancement of the activity of natural killer cells and cytotoxic T-lymphocytes. In this study, feline IL-18 cDNA was cloned and characterized to establish a basis for the prospective cytokine therapy in small animal practice. The nucleotide sequence of feline IL-18 cDNA obtained in this study was 712bp long and contained its entire open reading frame encoding 192 amino acid residues. The predicted amino acid sequence of feline IL-18 cDNA showed 77.2, 84.8, 60.2 and 62.6% similarity with those of human, dog, rat and mouse counterparts, respectively. The feline IL-18 cDNA included a putative cleavage site of IL-1beta-converting enzyme (ICE) and IL-1 signature-like sequences identified in human and mouse IL-18 cDNAs. Expression of IL-18 mRNA was detected in various tissues including spleen, liver and cerebrum in the cat.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0165-2427
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
30
|
| pubmed:volume |
79
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
209-18
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11389956-Amino Acid Sequence,
pubmed-meshheading:11389956-Animals,
pubmed-meshheading:11389956-Base Sequence,
pubmed-meshheading:11389956-Cats,
pubmed-meshheading:11389956-Cloning, Molecular,
pubmed-meshheading:11389956-DNA, Complementary,
pubmed-meshheading:11389956-Dogs,
pubmed-meshheading:11389956-Humans,
pubmed-meshheading:11389956-Interleukin-18,
pubmed-meshheading:11389956-Liver,
pubmed-meshheading:11389956-Mice,
pubmed-meshheading:11389956-Molecular Sequence Data,
pubmed-meshheading:11389956-RNA, Messenger,
pubmed-meshheading:11389956-Rats,
pubmed-meshheading:11389956-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11389956-Sequence Alignment,
pubmed-meshheading:11389956-Sequence Analysis, DNA,
pubmed-meshheading:11389956-Sequence Homology, Amino Acid,
pubmed-meshheading:11389956-Spleen,
pubmed-meshheading:11389956-Telencephalon
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Molecular cloning of feline interferon-gamma-inducing factor (interleukin-18) and its expression in various tissues.
|
| pubmed:affiliation |
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Science, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, 113-8657, Tokyo, Japan. aohno@mail.ecc.u-tokyo.ac.jp
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|