| pubmed-article:11389831 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11389831 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:11389831 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:11389831 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:11389831 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:11389831 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11389831 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11389831 | pubmed:dateCreated | 2001-6-6 | lld:pubmed |
| pubmed-article:11389831 | pubmed:abstractText | Embryos have evolved various strategies to confine the action of secreted signals. Using an HRP-Wingless fusion protein to track the fate of endocytosed Wingless, we show that degradation by targeting to lysosomes is one such strategy. Wingless protein is specifically degraded at the posterior of each stripe of wingless transcription, even under conditions of overexpression. If lysosomal degradation is compromised genetically or chemically, excess Wingless accumulates and ectopic signaling ensues. In the wild-type, Wingless degradation is slower at the anterior than at the posterior. This follows in part from the segmental activation of signaling by the epidermal growth factor receptor, which accelerates Wingless degradation at the posterior, thus leading to asymmetrical Wingless signaling along the anterior-posterior axis. | lld:pubmed |
| pubmed-article:11389831 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11389831 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389831 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11389831 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11389831 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:11389831 | pubmed:author | pubmed-author:VincentJ PJP | lld:pubmed |
| pubmed-article:11389831 | pubmed:author | pubmed-author:AlexandruSS | lld:pubmed |
| pubmed-article:11389831 | pubmed:author | pubmed-author:HirstEE | lld:pubmed |
| pubmed-article:11389831 | pubmed:author | pubmed-author:DuboisLL | lld:pubmed |
| pubmed-article:11389831 | pubmed:author | pubmed-author:LecourtoisMM | lld:pubmed |
| pubmed-article:11389831 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11389831 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11389831 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:11389831 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11389831 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11389831 | pubmed:pagination | 613-24 | lld:pubmed |
| pubmed-article:11389831 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:meshHeading | pubmed-meshheading:11389831... | lld:pubmed |
| pubmed-article:11389831 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11389831 | pubmed:articleTitle | Regulated endocytic routing modulates wingless signaling in Drosophila embryos. | lld:pubmed |
| pubmed-article:11389831 | pubmed:affiliation | National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, United Kingdom. | lld:pubmed |
| pubmed-article:11389831 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11389831 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:31118 | entrezgene:pubmed | pubmed-article:11389831 | lld:entrezgene |
| entrez-gene:32537 | entrezgene:pubmed | pubmed-article:11389831 | lld:entrezgene |
| entrez-gene:34009 | entrezgene:pubmed | pubmed-article:11389831 | lld:entrezgene |
| entrez-gene:37455 | entrezgene:pubmed | pubmed-article:11389831 | lld:entrezgene |
| entrez-gene:38168 | entrezgene:pubmed | pubmed-article:11389831 | lld:entrezgene |
| entrez-gene:40090 | entrezgene:pubmed | pubmed-article:11389831 | lld:entrezgene |
| entrez-gene:45307 | entrezgene:pubmed | pubmed-article:11389831 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:11389831 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:11389831 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11389831 | lld:pubmed |
