Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-6-6
pubmed:abstractText
Embryos have evolved various strategies to confine the action of secreted signals. Using an HRP-Wingless fusion protein to track the fate of endocytosed Wingless, we show that degradation by targeting to lysosomes is one such strategy. Wingless protein is specifically degraded at the posterior of each stripe of wingless transcription, even under conditions of overexpression. If lysosomal degradation is compromised genetically or chemically, excess Wingless accumulates and ectopic signaling ensues. In the wild-type, Wingless degradation is slower at the anterior than at the posterior. This follows in part from the segmental activation of signaling by the epidermal growth factor receptor, which accelerates Wingless degradation at the posterior, thus leading to asymmetrical Wingless signaling along the anterior-posterior axis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antimalarials, http://linkedlifedata.com/resource/pubmed/chemical/Chloroquine, http://linkedlifedata.com/resource/pubmed/chemical/Clathrin, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Frizzled Receptors, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Horseradish Peroxidase, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurotransmitter, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 Protein, http://linkedlifedata.com/resource/pubmed/chemical/deep orange protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/engrailed homeobox proteins, http://linkedlifedata.com/resource/pubmed/chemical/fz protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/fz2 protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/wg protein, Drosophila
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
613-24
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:11389831-Animals, pubmed-meshheading:11389831-Antimalarials, pubmed-meshheading:11389831-Chloroquine, pubmed-meshheading:11389831-Clathrin, pubmed-meshheading:11389831-DNA-Binding Proteins, pubmed-meshheading:11389831-Down-Regulation, pubmed-meshheading:11389831-Drosophila, pubmed-meshheading:11389831-Drosophila Proteins, pubmed-meshheading:11389831-Embryo, Nonmammalian, pubmed-meshheading:11389831-Endocytosis, pubmed-meshheading:11389831-Frizzled Receptors, pubmed-meshheading:11389831-Gene Expression Regulation, Developmental, pubmed-meshheading:11389831-Homeodomain Proteins, pubmed-meshheading:11389831-Horseradish Peroxidase, pubmed-meshheading:11389831-Lysosomes, pubmed-meshheading:11389831-Membrane Proteins, pubmed-meshheading:11389831-Protein Transport, pubmed-meshheading:11389831-Proto-Oncogene Proteins, pubmed-meshheading:11389831-Receptors, G-Protein-Coupled, pubmed-meshheading:11389831-Receptors, Neurotransmitter, pubmed-meshheading:11389831-Recombinant Fusion Proteins, pubmed-meshheading:11389831-Signal Transduction, pubmed-meshheading:11389831-Transcription Factors, pubmed-meshheading:11389831-Wnt1 Protein
pubmed:year
2001
pubmed:articleTitle
Regulated endocytic routing modulates wingless signaling in Drosophila embryos.
pubmed:affiliation
National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't