|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2001-5-28
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
One approach to the development of targeted cancer chemotherapy exploits increased uptake of the agent into neoplastic cells. In this scenario, higher concentrations of the agent in cancer cells are responsible for differential killing, whereas the low concentration in normal human cells decreases side effects. The aim of this study was to isolate an organic anion transporter that is weak in normal cells, but abundantly expressed in cancer cells, to deliver the anticancer drugs to the cells.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0016-5085
|
|
pubmed:author |
pubmed-author:AbeTT,
pubmed-author:AdachiHH,
pubmed-author:BRUCEM LML,
pubmed-author:DateFF,
pubmed-author:FujiwaraKK,
pubmed-author:IinumaKK,
pubmed-author:ItoSS,
pubmed-author:KakyoMM,
pubmed-author:KondoT NTN,
pubmed-author:KondoYY,
pubmed-author:MatsunoSS,
pubmed-author:NaguraHH,
pubmed-author:NakagomiRR,
pubmed-author:NishioTT,
pubmed-author:NunokiKK,
pubmed-author:OhtaniHH,
pubmed-author:OkabeMM,
pubmed-author:OnoKK,
pubmed-author:OnogawaTT,
pubmed-author:SatoEE,
pubmed-author:SekiMM,
pubmed-author:ShiibaKK,
pubmed-author:ShimosegawaTT,
pubmed-author:SugitaJJ,
pubmed-author:SuzukiMM,
pubmed-author:SuzukiTT,
pubmed-author:TanemotoMM,
pubmed-author:TokuiTT,
pubmed-author:UnnoMM
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
120
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1689-99
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11375950-Amino Acid Sequence,
pubmed-meshheading:11375950-Animals,
pubmed-meshheading:11375950-Anion Transport Proteins,
pubmed-meshheading:11375950-Antimetabolites, Antineoplastic,
pubmed-meshheading:11375950-Carrier Proteins,
pubmed-meshheading:11375950-Gastrointestinal Neoplasms,
pubmed-meshheading:11375950-Humans,
pubmed-meshheading:11375950-Immunohistochemistry,
pubmed-meshheading:11375950-Liver,
pubmed-meshheading:11375950-Methotrexate,
pubmed-meshheading:11375950-Molecular Sequence Data,
pubmed-meshheading:11375950-Xenopus laevis
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.
|
|
pubmed:affiliation |
Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University School of Medicine, Sendai, Japan. takaabe@mail.cc.tohoku.ac.jp
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
