Linked Life Data

11367741

Source:http://linkedlifedata.com/resource/pubmed/id/11367741

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-5-22
pubmed:abstractText
Extracellular single-unit discharges were obtained from 106 spontaneously active neurons in the region of the rostral ventrolateral medulla (RVLM) by glass microelectrode from 73 brain alices of Sprague-Dawley rats. Exogenous gamma-aminobutyric acid (GABA, 0.1-3.0 mmol/L) inhibited the electrical activity of 84 out of 106 RVLM neurons dose-dependently. The inhibitory effect of GABA could be blocked by GABAA receptor antagonist bicuculline methiodide (BMI) and Cl- channel blocker picrotoxin (PTX). When perfused with BMI or PTX alone, the firing rates of most of the RVLM neurons were significantly increased. In 41 neurons responding to GABA, baclofen (0.1-3.0 mumol/L), a GABAB receptor selective agonist, inhibited the discharges of 33 of the neurons dose-dependently. GABAB receptor antagonist CGP35348 (n = 13) blocked the inhibition due to baclofen (n = 21). After perfused with CGP35348 alone, the firing rates of most of the RVLM neurons were significantly increased. Taken together, the inhibition of GABA on RVLM neurons is mediated through either GABAA or GABAB receptors and some intrinsic GABA neurons exert tonic inhibition activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0371-0874
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
483-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Inhibitory effect of GABA on firing activity of rostral ventrolateral medullary neurons of rat in vitro.
pubmed:affiliation
Department of Physiology, Shanghai Medical University, Shanghai 200032.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't