Linked Life Data

11343626

Source:http://linkedlifedata.com/resource/pubmed/id/11343626

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-5-23
pubmed:abstractText
The pathogenesis of major depression (MD) remains unclear despite intensive research in the last decades which brought up a multitude of findings illustrating the complexity of this disorder. In this paper we will summarize the evidence pointing towards a structural alteration of the basal limbic system in MD and depression in Parkinson's disease (PD). Transcranial ultrasound and MRI studies in both depressive syndromes revealed altered signal intensity of the brainstem midline comprising fibre tracts of the basal limbic system. The hypothesis of a structural disruption of the basal limbic system is supported by biochemical and histopathological findings. The similarity of findings in MD and depression in PD might reflect a relationship between MD and neurodegenerative disorders.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1461-1457
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Basal limbic system alteration in major depression: a hypothesis supported by transcranial sonography and MRI findings.
pubmed:affiliation
Neurologische Universitätsklinik W?rzburg, Germany. georg.becker@mail.uni-wuerzburg.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't