Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2001-5-3
pubmed:abstractText
We analyzed the expression and function of eyeless (ey) and twin of eyeless (toy) in the embryonic central nervous system (CNS) of Drosophila. Both genes are differentially expressed in specific neuronal subsets (but not in glia) in every CNS neuromere, and in the brain, specific cell populations co-expressing both proteins define a longitudinal domain which is intercalated between broad exclusive expression domains of ey and toy. Studies of genetic null alleles and dsRNA interference did not reveal any gross neuroanatomical effects of ey, toy, or ey/toy elimination in the embryonic CNS. In contrast, targeted misexpression of ey, but not of toy, resulted in profound axonal abnormalities in the embryonic ventral nerve cord and brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/PAX6 protein, http://linkedlifedata.com/resource/pubmed/chemical/Paired Box Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Double-Stranded, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/eyeless protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/twin of eyeless protein, Drosophila
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0925-4773
pubmed:author
pubmed:issnType
Print
pubmed:volume
103
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11335113-Alleles, pubmed-meshheading:11335113-Animals, pubmed-meshheading:11335113-Central Nervous System, pubmed-meshheading:11335113-Crosses, Genetic, pubmed-meshheading:11335113-DNA-Binding Proteins, pubmed-meshheading:11335113-Drosophila, pubmed-meshheading:11335113-Drosophila Proteins, pubmed-meshheading:11335113-Eye Proteins, pubmed-meshheading:11335113-Homeodomain Proteins, pubmed-meshheading:11335113-Immunohistochemistry, pubmed-meshheading:11335113-In Situ Hybridization, pubmed-meshheading:11335113-Microscopy, Confocal, pubmed-meshheading:11335113-Paired Box Transcription Factors, pubmed-meshheading:11335113-Protein Structure, Tertiary, pubmed-meshheading:11335113-RNA, Double-Stranded, pubmed-meshheading:11335113-Repressor Proteins, pubmed-meshheading:11335113-Tissue Distribution, pubmed-meshheading:11335113-Trans-Activators
pubmed:year
2001
pubmed:articleTitle
Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development.
pubmed:affiliation
Institute of Zoology, Biocenter/Pharmacenter, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't