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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2001-4-30
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pubmed:abstractText |
The design and synthesis of a new potent and selective inhibitor of the respiratory syncytial virus are described. This compound, RFI-641, emerged from analysis of the structure-activity relationship in a series of biphenyl triazine anionic compounds possessing specific anti-RSV activity. The key synthetic step involves coupling of diaminobiphenyl 11 with two equivalents of chlorotriazine 10 under microwave conditions. RFI-641 inhibited RSV in vitro and in vivo models.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1041-4
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11327584-Animals,
pubmed-meshheading:11327584-Antiviral Agents,
pubmed-meshheading:11327584-Cells, Cultured,
pubmed-meshheading:11327584-Cercopithecus aethiops,
pubmed-meshheading:11327584-Cytomegalovirus,
pubmed-meshheading:11327584-Disease Models, Animal,
pubmed-meshheading:11327584-Drug Design,
pubmed-meshheading:11327584-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:11327584-Herpesvirus 1, Human,
pubmed-meshheading:11327584-Humans,
pubmed-meshheading:11327584-Inhibitory Concentration 50,
pubmed-meshheading:11327584-Mice,
pubmed-meshheading:11327584-Nose,
pubmed-meshheading:11327584-Rats,
pubmed-meshheading:11327584-Respiratory Syncytial Virus Infections,
pubmed-meshheading:11327584-Respiratory Syncytial Viruses,
pubmed-meshheading:11327584-Sensitivity and Specificity,
pubmed-meshheading:11327584-Structure-Activity Relationship,
pubmed-meshheading:11327584-Sulfonamides,
pubmed-meshheading:11327584-Triazenes,
pubmed-meshheading:11327584-Triazines
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pubmed:year |
2001
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pubmed:articleTitle |
The discovery of RFI-641 as a potent and selective inhibitor of the respiratory syncytial virus.
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pubmed:affiliation |
Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA. nikitea@war.wyeth.com
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pubmed:publicationType |
Journal Article
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